Antitumor effect of Verbascum phlomoides L. on Ehrlich carcinoma tumor cells
August 9, 2019
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| Article Title: | Antitumor effect of Verbascum phlomoides L. on Ehrlich carcinoma tumor cells |
| Authors: | Stan R., L., Vicaș L., G., Hangan A., C., Sarpataki O., Ionescu C., Marian E., Sevastre-Berghian A., C., Jurca T., Sevastre B |
| Affiliation: | 1University of Medicine and Pharmacy “Iuliu Hațieganu”, Faculty of Pharmacy, Emil Isaac Street 13, 400023, Cluj-Napoca, Romania 2Faculty of Medicine and Pharmacy, University of Oradea, Nicolae Jiga Street 29, 410610, Oradea, Romania 3University of Agricultural Science and Veterinary Medicine, Faculty of Veterinary Medicine, Mănăștur Street 3-5, 400372, Cluj-Napoca, Romania 4University of Medicine and Pharmacy “Iuliu Hațieganu”, Faculty of Medicine, Emil Isaac Street 13, 400023, Cluj-Napoca, Romania |
| Abstract: | Mullein is a plant widespread in the wild flora of Romania, but less used in traditional medicine and with less demonstrated effects. The aim of the present study was to demonstrate the in vivo antitumor activity of Verbascum phlomoides L. harvested from Romania and its ability to achieve protection against the side effects caused by the tumor growth. We carried out the study on 32 Mus musculus female mice, over a two week period. The tumor model was Ehrlich Ascites Carcinoma (EAC). Animals were divided in four equal groups of 8 mice: control, tumor control, EAC + doxorubicin and EAC + Verbascum phlomoides L. Doxorubicin was used as antitumor reference. Difference in body weight, EAC volume and tumor cell concentration were improved in significant manner. Hematological and biochemistry parameters determination were performed and no cytotoxicity was found. Therefore Verbascum phlomoides L. is recommended for further studies, in other to find new remedies in complementary cancer therapy. |
| Keywords: | antitumor, Ehrlich Ascitic Carcinoma, mice, Verbascum phlomoides L., Doxorubicin |
| *Correspondence: | Adriana Corina Hangan, University of Medicine and Pharmacy “Iuliu Hațieganu”, Faculty of Pharmacy, Emil Isaac Street 13, 400023, Cluj-Napoca, Romania, Tel. +40-(0722)413801, email: acomsa6@yahoo.com |
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