Ribes nigrum fruit extract shows cardioprotective properties in experimental acute ischemic heart disease
February 15, 2019
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| Article Title: | Ribes nigrum fruit extract shows cardioprotective properties in experimental acute ischemic heart disease |
| Authors: | Gubina – Vakulyck G., I., Gorbach T., V., Tkachenko A., S., Domarev A., P., Martynova S., M., Denysenko S., A., Shcholok T., T., Molchanova A., V |
| Affiliation: | 1Department of Pathological Anatomy, Kharkiv National Medical University, Kharkiv, Ukraine 2Department of Biochemistry, Kharkiv National Medical University, Kharkiv, Ukraine 3Department of Biotechnology, National Technical University “Kharkiv Polytechnic Institute”, Kharkiv, Ukraine |
| Abstract: | The study was designed to assess antioxidant and cardioprotective properties of antioxidants-containing blackcurrant (Ribes nigrum) extract in experimental adrenaline-induced acute ischemic heart disease. The content of troponin-1 and myoglobin, the activity of creatine phosphokinase MB in blood serum and levels of TBA-reactive substances, reduced glutathione and ATP, as well as the activity of superoxide dismutase, catalase, alanine aminotransferase and aspartate aminotransferase in myocardial homogenates were determined in control intact animals and in rats with adrenaline-induced acute ischemic heart disease untreated and treated with the blackcurrant extract. Our findings suggest that the Ribes nigrum fruit extract administration at a dose of 0.1 ml / 100g of body weight results in activation of antioxidant system and energy metabolism in myocardium and normalization of redox metabolism. |
| Keywords: | blackcurrant, antioxidants, anthocyanins, ischemic heart disease |
| *Correspondence: | Anton Tkachenko, Kharkiv National Medical University,, Department of Biochemistry, Nauky ave 4, 61022, Kharkiv, Ukraine, Tel. +38050-109-45-54, Fax. +38(057)700-41-32, email: antontkachenko555@gmail.com |
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