Qualitative assessment of some hydrogels containing ketoprofen
November 17, 2014
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| Article Title: | Qualitative assessment of some hydrogels containing ketoprofen |
| Authors: | Toderescu C.D., Dinu-Pîrvu C.E., Ghica M.V., Anuţa V., Vlaia L., Lupuliasa D. |
| Affiliation: | 1Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2Faculty of Pharmacy, Department of Pharmaceutical Sciences, ”Vasile Goldis” Western University of Arad, Romania 3Faculty of Pharmacy, University of Medicine and Pharmacy, Timisoara, Romania |
| Abstract: | This paper is a complex biopharmaceutical study that analyses the formulation of some hydrogels intended for cutaneous use, which favour a rapid release of the active substance from the designed vehicles onto and through the skin surface. The influence of the gel-forming polymer type on the main quality parameters of hydrogels with ketoprofen was assessed. Through the experiments conducted the organoleptic control, pH determination, drug content and spreadability were carried out for the formulations. A study of the rheological properties characteristic for the designed hydrophilic gels was also performed and the relation between their flow properties and both the structure and composition was further analyzed. This characterization contributes to the design evaluation and the optimization of semisolid pharmaceutical systems, in order to be used for specific purposes. |
| Keywords: | carbomer 940, hydroxyethylcellulose, ketoprofen, hydrogel |
| *Correspondence: | Cristina Elena Dinu-Pîrvu, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania ecristinaparvu@yahoo.com |
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