In vitro studies on the relationship between anti Helicobacter pylori therapy and carbonic anhydrase isoenzymes II and IV

November 17, 2014

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Article Title:	In vitro studies on the relationship between anti Helicobacter pylori therapy and carbonic anhydrase isoenzymes II and IV
Authors:	Dume C.A., Puscas I.
Affiliation:	1 Regional Gastroenterology and Hepatology Institute “Prof. O. Fodor” Cluj Napoca; 2 Municipal Hospital “Prof. Dr. Ioan Puscas” Simleul Silvaniei
Abstract:	H+/K+ ATPase discovery resulted in the re-evaluation of the role of carbonic anhydrase (CA) in acid secretion. In addition to its traditional role, proposed by Davenport as a source of H + ions by catalytic hydration of CO2 in the current biochemical model of acid secretion, CA is involved in segregation of H+ and OH- ions in the parietal cell. In our study we observed the effect of anti H. pylori therapy on the two isoenzymes of CA involved in acid secretion changes. The study was conducted in terms of two experiments: the dose – response and kinetic studies. The results of this study mainly confirms the implication of CA II and CA IV in the mechanism of gastric acid secretion also explaining the beneficial effects of combination therapy in the treatment of H. pylori infection as a result of gastric mucosa CA isoenzymes inhibition.
Keywords:	Helicobacter pylori, Carbonic anhydrase
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*Correspondence:	Dume Anca Claudia, Regional Gastroenterology and Hepatology Institute “Prof. O. Fodor” Cluj Napoca Tel. 0740169946, email: ancadume@ymail.com