Quantum dots based multifunctional nanosystems for theranostic applications
November 17, 2014
 |
Read full article |
| Article Title: | Quantum dots based multifunctional nanosystems for theranostic applications |
| Authors: | Cinteza L. O., Ailiesei I., Petrache S., Dinischiotu A. |
| Affiliation: | University of Bucharest, Chemistry Faculty, Physical Chemistry Department, Bucharest University of Medicine and Pharmacy ”Carol Davila” Bucharest, Faculty of Pharmacy, Bucharest. University of Bucharest, Biology Faculty, Bucharest |
| Abstract: | A facile method to obtain multifunctional nanosystems encapsulating both imaging agents and drug molecules is presented in this work. One of the modern concepts in the therapy of cancer diseases is “theranostic” (from therapy + diagnostics), that means the application of multifunctional systems to deliver the chemotherapeutic drug and the use of fluorescence agent for the imaging the treatment efficiency by monitoring the effect of the active substance on the targeted tumoral cells. The silica nanoparticles were used as matrix to encapsulate quantum dots as bioimaging agents, as they are easy to be prepared as water dispersible and stable in the physiological environment. Quantum dots from CdTe were prepared using a simple hydrothermal method, with citrate and hydrophilic polymer as stabilizer. The anticancer drug Topotecan was used as chemotherapeutic agent, coencapsulated with the semiconducting nanocrystals into the silica matrix. The complex theranostic systems were characterized by using DLS and TEM. Optical properties of the quantum dots were investigated using fluorescence spectra in various environments. The possibility to use the silica fluorescent nanosystems with Topotecan content in bioimaging was studied using fluorescence microscopy on HeLa cell culture. |
| Keywords: | theranostic, cancer, nanosystems, quantum dots |
| References: | |
| *Correspondence: | Ludmila Otilia Cinteza, University of Bucharest, Faculty of Chemistry, Physical Chemistry Department, 4-12 Elisabeta Blvd., 030118, Bucharest, Romania, Tel. +40- (21)-3050767, Fax. +40-(21)- 3159249, email: ocinteza@gwchimie.math.unibuc.ro |
Magnetic hyperthermia on mouse B16 melanoma using superparamagnetic nanoparticles
Development and optimization of alendronate loaded liposomes for oral administration by using response surface methodology
NWA a discrete stochastic simulation technique: a review
About The Author
