Porous pellets a possibility to obtain a modify release for metoprolol salts
March 21, 2013
Porous pellets a possibility to obtain a modify release for metoprolol salts
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| Title: | Porous pellets a possibility to obtain a modify release for metoprolol salts |
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| Article_Title: | Porous pellets – a possibility to obtain a modify release for metoprolol salts |
| Authors: | Marouj Daas, Dumitru Lupuleasa, Doina Draganescu, Ali Hamze Mourad |
| Affiliation: | University of Medicine and Pharmacy,,Carol Davila” Bucharest, Departament of Pharmeaceutical Technology and Biopharmacy University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Physics, 6 Traian Vuia, 020956 |
| Abstract: | This study have the objective to obtain porous pellets consisting in a mix of HPMC (hidroxypropylmethylcellulose) and xanthan gum or alginates salts or carrageens salts, and calcium salts soluble in water as gelling agent. This pellets after the removal of the calcium ions via extraction with water was evaluated by loading techniques to incorporate metoprolol salts by two techniques: fluid bed and immersing in a drug solutions. The pellets obtained by extrusion and spheronisation was characterized from residual content in calcium ions, friability and drug loading. The pellets obtained can be used as carriers from metoprolol salts (succinates and tartrate). The drug loading studies have shown that immersing the pellets in a drug solution are able to deposit metoprolol salts inside. Using fluidized bed coating no drug was found inside the porous pellets. |
| Keywords: | alginates salts, carrageens salts, and calclium salts soluble in water gelling agent, extrusion, hidroxypropylmethylcellulose, metoprolol salts (succinates and tartrate), spheronisation, xanthan gum. |
| References: | 1. Ahmad Bani-jaber, Mutasin Al-Ghazani,,Sustained Release Characteristics of Tablets Prepared with Mixed Matrix of sodium carrageens and chitosan” Drug Development and Industrial Pharmacy, vol 30, nr 2, pp 143-150, 2004 3. Crina-Maria Monciu,,Analiza chimică în controlul medicamentelor”, Ed. Medicală, Bucureşti, 2005 4. M. C. Gohel, A. F. Amin, K. V. Patel and M. K. Panchal,,Studies in release behavior of diltiazem HCl form matrix tablets containing hydroypropyl methyl cellulose and xanthan gum”, Boll.Chim. Farmac., 141: 21-28 (2002) 5. T. Gold, N. Shterman, Metoprolol succinate extended release tablets and methods for their preparation, European patent EP18452534, June, 2007 6. Irina Prasacu, Constantin Mircioiu, Roxana Sandulovici, Florin Enache,,Release of matoprolol from solid dosage forms. Choice and validation of theoretical model” Farmacia 1 pp 89 (2000) Porous pellets – a possibility to obtain a modify release for metoprolol salts 338 Studia Universitatis “Vasile Goldiş”, Seria Ştiinţele Vieţii Vol. 21, issue 2, 2011, pp. 335-338 ©2011 Vasile Goldis University Press (www.studiauniversitatis.ro) 7. I. Kusai, L. Vlase, I. Tomuţă, S. E. Leucuţa,,Kinetic modeling of hydration hydrophilic matrices with diclofenac sodium on basis of hydroxypropylmethylcellulose and xanthan gum” Farmacia 4, pp 371-380 (2008) 8. E. Mendel,,Controlled release metoprolol oral composition containing heteropolysaccharides and method for the preparation thereof” US patent 5399362, April, 1995 9. Michael A. Odeniyi, Kolowole T. Jaiiyeobe,,Optimization of ascorbic acid tablet formulation containing hydrophilic polymers” Farmacia2, vol 5, pp 157 (2009). 10. Simona Raicu, Lelia Lazăr,,Release properties of a biodegradable hydrophylic matrix with alginates” Farmacia 7-8, pp 101-105 11. N. J. Sune, P.M.,,A process for the preparation of controlled-release pharmaceutical composition of metoprolol” PCT patent application WO 20055084636 September. 2005 12. M.V. Shteinhart,,Tablet with controlled release of metoprolol” Ukraina patent UA135IU Feb, 2006 12. Syed Nissar Hussain Shah, Sajid Asghar, Muhammad Akram Choudhry, Muhammad Sajid Hamid Akash, formulation and evaluation of natural gum based sustained release matrix tablets of flurbiprofen using response surface methodology” D.D.I.Ph. 35 (12): 1470 – 1479, 2009 14. J. Sujiaareth, D. L. Munday, P. J.Cox and K. A. Khan,,Relationship between swelling, erosion and drug release from hydrophilic natural gum minimatrix formulation, Eur. J. Pharm. Sci 6:207-217 (1998) 15. M. M. Talukdar, A. Michel, P. Rombaut and Kinget,,Comparative study on xanthan gum and hydroxypropylmethyl celluloses matrices for controlled-release drug delivery” Int. J. Pharm. 129, 233-241 (1998) 16. *** European Pharmacopeia, ed. 5, vol 2 17. *** US patent 4879362/2008 18. *** US patent 7838032/2010 |
| Read_full_article: | pdf/21-2011/21-2-2011/SU21-2-2011Daas.pdf |
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| Article Title: | Porous pellets – a possibility to obtain a modify release for metoprolol salts |
| Authors: | Marouj Daas, Dumitru Lupuleasa, Doina Draganescu, Ali Hamze Mourad |
| Affiliation: | University of Medicine and Pharmacy,,Carol Davila” Bucharest, Departament of Pharmeaceutical Technology and Biopharmacy University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Physics, 6 Traian Vuia, 020956 |
| Abstract: | This study have the objective to obtain porous pellets consisting in a mix of HPMC (hidroxypropylmethylcellulose) and xanthan gum or alginates salts or carrageens salts, and calcium salts soluble in water as gelling agent. This pellets after the removal of the calcium ions via extraction with water was evaluated by loading techniques to incorporate metoprolol salts by two techniques: fluid bed and immersing in a drug solutions. The pellets obtained by extrusion and spheronisation was characterized from residual content in calcium ions, friability and drug loading. The pellets obtained can be used as carriers from metoprolol salts (succinates and tartrate). The drug loading studies have shown that immersing the pellets in a drug solution are able to deposit metoprolol salts inside. Using fluidized bed coating no drug was found inside the porous pellets. |
| Keywords: | alginates salts, carrageens salts, and calclium salts soluble in water gelling agent, extrusion, hidroxypropylmethylcellulose, metoprolol salts (succinates and tartrate), spheronisation, xanthan gum. |
| References: | 1. Ahmad Bani-jaber, Mutasin Al-Ghazani,,Sustained Release Characteristics of Tablets Prepared with Mixed Matrix of sodium carrageens and chitosan” Drug Development and Industrial Pharmacy, vol 30, nr 2, pp 143-150, 2004 3. Crina-Maria Monciu,,Analiza chimică în controlul medicamentelor”, Ed. Medicală, Bucureşti, 2005 4. M. C. Gohel, A. F. Amin, K. V. Patel and M. K. Panchal,,Studies in release behavior of diltiazem HCl form matrix tablets containing hydroypropyl methyl cellulose and xanthan gum”, Boll.Chim. Farmac., 141: 21-28 (2002) 5. T. Gold, N. Shterman, Metoprolol succinate extended release tablets and methods for their preparation, European patent EP18452534, June, 2007 6. Irina Prasacu, Constantin Mircioiu, Roxana Sandulovici, Florin Enache,,Release of matoprolol from solid dosage forms. Choice and validation of theoretical model” Farmacia 1 pp 89 (2000) Porous pellets – a possibility to obtain a modify release for metoprolol salts 338 Studia Universitatis “Vasile Goldiş”, Seria Ştiinţele Vieţii Vol. 21, issue 2, 2011, pp. 335-338 ©2011 Vasile Goldis University Press (www.studiauniversitatis.ro) 7. I. Kusai, L. Vlase, I. Tomuţă, S. E. Leucuţa,,Kinetic modeling of hydration hydrophilic matrices with diclofenac sodium on basis of hydroxypropylmethylcellulose and xanthan gum” Farmacia 4, pp 371-380 (2008) 8. E. Mendel,,Controlled release metoprolol oral composition containing heteropolysaccharides and method for the preparation thereof” US patent 5399362, April, 1995 9. Michael A. Odeniyi, Kolowole T. Jaiiyeobe,,Optimization of ascorbic acid tablet formulation containing hydrophilic polymers” Farmacia2, vol 5, pp 157 (2009). 10. Simona Raicu, Lelia Lazăr,,Release properties of a biodegradable hydrophylic matrix with alginates” Farmacia 7-8, pp 101-105 11. N. J. Sune, P.M.,,A process for the preparation of controlled-release pharmaceutical composition of metoprolol” PCT patent application WO 20055084636 September. 2005 12. M.V. Shteinhart,,Tablet with controlled release of metoprolol” Ukraina patent UA135IU Feb, 2006 12. Syed Nissar Hussain Shah, Sajid Asghar, Muhammad Akram Choudhry, Muhammad Sajid Hamid Akash, formulation and evaluation of natural gum based sustained release matrix tablets of flurbiprofen using response surface methodology” D.D.I.Ph. 35 (12): 1470 – 1479, 2009 14. J. Sujiaareth, D. L. Munday, P. J.Cox and K. A. Khan,,Relationship between swelling, erosion and drug release from hydrophilic natural gum minimatrix formulation, Eur. J. Pharm. Sci 6:207-217 (1998) 15. M. M. Talukdar, A. Michel, P. Rombaut and Kinget,,Comparative study on xanthan gum and hydroxypropylmethyl celluloses matrices for controlled-release drug delivery” Int. J. Pharm. 129, 233-241 (1998) 16. *** European Pharmacopeia, ed. 5, vol 2 17. *** US patent 4879362/2008 18. *** US patent 7838032/2010 |
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