Features of EGFR expression in the head and neck squamous cell carcinoma

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Article Title:	Features of EGFR expression in the head and neck squamous cell carcinoma
Authors:	Elisabeta Maria Vasca, Caius Doros, Virgil Vasca, Raluca Amalia Ceausu, Pusa Gaje, Tatiana Duminica, Marius Raica
Affiliation:	Faculty of Medicine, Pharmacy and Dental Medicine, ’’Vasile Goldis” Western University Arad, Romania ”Victor Babes” University of Medicine and Pharmacy, Department of Histology, Angiogenesis Research Center Timisoara, Romania “Victor Babes” University of Medicine and Pharmacy, Department of Maxillofacial Surgery, Timisoara, Romania ”Victor Babes” University of Medicine and Pharmacy, ENT Department, Timisoara, Romania
Abstract:	Head and neck comprise a wide spectrum of neoplasms with different tumor biologies, prognosis and response to therapies. The most common histology of head and neck tumor is squamous cell carcinoma. Disappointigly, until now, survival has not markedly improved because the patients still frequently develop locoregional recurrences, distant metastasis and different second tumours. The purpose of the present study was the assessment of the EGFR expression in the squamous cell carcinoma with different localization in the area of the head and neck. We included in the study a number of 17 biopsy fragments from patients diagnosed with squamous cell carcinoma: from the larynx area (5), from the pharynx area (2), the hard palate (1), tongue (2), submandibular (1), lip (2), gingival sulcus (1), nasal pyramid (1), maxilla (1), zygomatic (1). The immunoreaction for EGFR was evaluated according with the following score: 0 (0% positive cells), 1 (<10% positive cells), 2 (10-30%), 3 (>30%). The value 3 of score was noticed in half of the cases included in the study. This was present in each type, excepted the squamous cell carcinomas from the submandibulary, maxillary and zygomatic areas. Heterogeneous distribution, more intense in the cells from the periphery of the tumoral areas were noticed in the case of the squamous cell carcinoma from the areas of the larynx, lip, nasal pyramid. A new classification of HNSCC based on molecular features of each tumor subtype could improve the diagnosis of these diseases and also can cause a better stratification of the patients who will be followed then by a more targeted therapeutic schemes.
Keywords:	EGFR, head and neck squamous cell carcinoma
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