Evaluation the relationship between oxidative stress parameters and lipidic profile in stable angina

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Article Title:	Evaluation the relationship between oxidative stress parameters and lipidic profile in stable angina
Authors:	Diana Alina Bel, Barbu Cuparencu, Adriana Salajan, Annamaria Pallag
Affiliation:	University of Oradea, Faculty of Medicine and Phanmacy Departement of Pharmacology University of Oradea, Faculty of Medicine and Pharmacy Departement of Internal Medicine University of Oradea, Faculty of Medicine and Phanmacy Departement of Pharmacy
Abstract:	Oxidative stress can be considered an imbalance between generation of reactive oxygen species and antioxidant defense system. Cellular ROS fonmation is a physiologic process in the vasculature and oc:c:urs in endothelial and smooth muscle cells as well as fibroblasts. Although ROS are small, structurally simple molecules with high and random reactivity, they appear to be subtle physiologic modulators of biochemical processes involved in intracellular signaling. Stable angina as cardinal manifestation of ischemic heart disease, has attracted our attention, causing initiation of a study to track the benefits of phanmacological treatment in this condition. We investigated variations of antioxidant status and oxidative stress parameters in conrelation with modifications of lipidic profile under antianginal drugs treatment. The association of beta blockers with Ca antagonists reduced the oxidative stress and has a positive effect on the lipidic profile.
Keywords:	antioxidant status, oxidative stress, stable angina, antianginal drugs
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*Correspondence:	Bei Diana Alina, Universitatea din Oradea, Facultatea de Medicina si Farmacie Oradea, str 1 Decembrie Nr. 10, Phone: 0259415680, E-mail: diana_bei@yahoo.oom