Interrelations of drying heat and survival of different fungal spores within the tablets formulation

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Article Title:	Interrelations of drying heat and survival of different fungal spores within the tablets formulation
Authors:	Oday Husham Kamil, Dumitru Lupuliasa, Doina Draganescu, Lavinia Vlaia
Affiliation:	University of Baghdad, faculty of Pharmacy, Iraq University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Technology, 6 Traian Vuia, 020956 University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Physics, 6 Traian Vuia, 020956 University of Medicine and Pharmacy “Victor Babes” Timisoara, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eftimie Murgu, 300041
Abstract:	The level of temperature plays an important role in the survival of the microorganisms, the different species of molds must grow and develop at any temperature their environment is. However, high temperature for a certain period will cause the death of microorganisms. In this study the objective is to investigate the interrelations of drying heat (55 oC for 30 minutes) used in tablets manufacture on the survival of different fungal spores (Aspergillus flavus and Penicillium spp.) at different contamination levels (102, 104 and 106) (spores/g) within the prepared tablets. The results showed that the drying heat caused the inactivation of about 32% of Aspergillus flavus spores and 36.6 % of Penicillium spp. spores within the granules. In addition, the level of inactivation decrease with increasing the contamination level, especially with 106 (spores/g) which may be related to the possibility of mutation that lead to enhance the resistance toward heat.
Keywords:	Tablets manufacture; drying heat; fungal spores survival
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