The prognostic value of microvascular density in lung carcinomas

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Article Title:	The prognostic value of microvascular density in lung carcinomas
Authors:	Amalia Birau, Raluca Amalia Ceausu, Anca Maria Cimpean, Pusa Gaje, Stefana Feflea, Gheorghe Ciobanu, Teodora Olariu, Marius Raica
Affiliation:	1Department of Intensive Care*, Department of Radiology **„Vasile Goldis” Western University of Arad 2”Victor Babes” University of Medicine and Pharmacy, Department of Histology, Angiogenesis Research Center Timisoara, Romania
Abstract:	As one of the first quantifiable methods used in the study of angiogenesis, microvascualar density was performed to all currently known tumors, including lung cancer. There are still numerous controversies regarding the prognostic value of microvascular density. For these reasons, the aim of this study was to investigate the morphology and the density of blood vessels in different pathological types of lung carcinomas using CD34 as antibody. We have included in our study 42 patients. In small cell lung carcinomas, CD34-positive vessels were significantly less in comparison with adenocarcinomas. The peritumoral vessels were significantly more numerous than the intratumoral, excepting for large cell lung carcinomas. The lowest values of microvascular density were found for small cell lung carcinomas. We found statistically significant correlation between microvascular density, tumor stage (p<0.00021) and the degree of differentiation (p<0.0032). Although MVD can be a useful prognostic element, there are enough data to support its role for assessing efficiency of anti-angiogenic therapy.
Keywords:	angiogenesis, microvascular density, lung carcinomas, prognosis
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*Correspondence:	Amalia Birau, MD, PhD student, Department of Intensive Care, „Vasile Goldis” Western University of Arad, no.1 Feleacului St., Arad, Romania, Tel: +40-257-212204; birauamalia@yahoo.com