Primary and metastatic malignant tumors of the liver
September 18, 2011
Primary and metastatic malignant tumors of the liver
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Title: | Primary and metastatic malignant tumors of the liver |
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Article_Title: | Primary and metastatic malignant tumors of the liver |
Authors: | Norina Basa1, Elena Lazăr2, Marioara Cornianu2, Alis Dema2, Sorina Tăban2, Daniela Lazăr3, Mirela Grigoraş2 |
Affiliation: | 1Municipal Hospital Timisoara, Romania; 2Department of Pathology Timisoara, Romania; 3Gastroenterology Clinic University of Medicine and Pharmacy “Victor Babeş” Timişoara, Romania |
Abstract: | The liver represents the most common localization of primary and metastatic hepatic tumors. This paper aims to review hepatic premalignant lesions and the histopathological classification of malignant tumors of the liver, describing the main growth patterns, citoarchitectural features and immunohistochemical profile of epithelial and mesenchymal hepatic tumors. Clinical aspects, differential diagnosis criteria and developmental-prognostic behavior are discussed. |
Keywords: | hepatic tumors, hepatocellular carcinoma, immunohistochemisty, Hep Par-1, α-fetoprotein |
References: | Anthony P.P. Tumors and tumor-like lesions of the liver and biliary tract. In: MacSween R.N.M., Anthony P.P., Scheuer P.J., et al., eds. Pathology of the liver, 4th ed. Edinburgh:Churchill Livingstone, 2002. De Souza A., Yamada T., Mills J.J., et al. Imprinted genes in liver carcinogenesis. FASEB J 1997; 11:60-67. Stuart K.E., Anand A.J., Jenkins R.L. Hepatocellular carcinoma in the United States: prognostic features, treatment outcome and survival. Cancer 1996; 77:2217-2222. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995; 22:983- 993. Ishak K.G., Anthony P.P., Sobin L.H. Histological typing of tumors of the liver. In:World Health Organization international histological classification of tumors, 2nd ed. Berlin: Springer-Verlag, 1994. Subramony C., Herrera G.A., Lockard V. Neuroendocrine differentiation in hepatic neoplasms: report of four cases. Surg Pathol 1993; 5:17-33. Lau S., Prakash S., Geller S.A., et al. Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma and metastatic adenocarcinoma. Hum Pathol 2002; 33:1175-1181. Craig J.R., Peters R.L., Edmondson H.A. Tumors of the liver and intrahepatic bile ducts. In: Atlas of tumor pathology, 2nd series, fascicle 26. Washington D.C: Armed Forces Institute of Pathology, 1989. Haratake J., Horie A. An immunohistochemical study of sarcomatoid liver carcinomas. Cancer 1991; 68:93-97. Hood D.L., Bauer T.W., Leibel S.A., et al. Hepatic giant cell carcinoma. An ultrastructural and immunohistochemical study. Am J Clin Pathol 1990; 93:111-116. LeBrun D.P., Silver M.M., Freedman M.H., et al. Fibrolamellar carcinoma of the liver in a patient with Fanconi anemia. Hum Pathol 1991; 22:396- 398. Ma C.K., Zarbo R.J., Frierson H.F., et al. Comparative immunohistochemical study of primary and metastatic carcinomas of the liver. Am J Clin Pathol 1993; 99:551-557. Ljubimova J.Y., Petrovic L.M., Wilson S.E., et al. Gene expression of HGF, its receptor (c-met), c-myc and albumin in cirrhotic and neoplastic human liver tissue. J Histochem Cytochem 1997; 45:79-87. Ojanguren I., Ariza A., Llatos M., et al. Proliferating cell nuclear antigen in normal, regenerative and neoplastic liver. Hum Pathol 1993; 24:905-908. An C., Petrovic L.M., Reyter I., et al. The application of neutal network technology to the study of large cell dysplasia and hepatocellular carcinoma. Hepatology 1997; 26:1224-1231. Wanless I., Callea F., Craig J., et al. Terminology of nodular lesions of the liver. Hepatology 1995; 25:983-993. Natarajan S., Theise N.D., Thung S.N., et al. Large-cell change of hepatocytes in cirrhosis may present a reaction to prolonged cholestasis. Am J Surg Pathol 1997; 21:312-318. Su Q., Benner A., Hofmann W.J., et al. Human hepatic preneoplasia: phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia. Virchows Arch 1997; 431:391-406. Ishak K.G., Goodman Z.D., Stocker J.T. Tumors of the liver and intrahepatic bile ducts. Armed Forces Institute of Pathology, Washington DC 2001; 9-48. Ferrell L. Hepatocellular nodules in the cirrhotic liver: diagnostic features and proposed nomenclature. In: Ferrell L. (ed.) Diagnostic problems in liver pathology. Pathology: state of the art reviews. Hanley & Belfus, Philadelphia 1994; 105-117. Ferrell L., Crawford J., Dhillon A., et al. Proposal for standardized criteria for the diagnosis of benign, borderline and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 1993; 17:1113-1123. Koneru B., Flye M.W., Busuttil R.W., et al. Liver transplantation for hepatoblastoma: the American Experience. Ann Surg 1991; 213:118-121. Wakely P.E. Jr., Silverman J.F., Geisinger K.R., et al. Fine needle aspiration biopsy cytology of hepatoblastoma. Mod Pathol 1990; 3:688-693. Goldstein R.M., Stona M., Tillery G.W., et al. Is liver transplantation indicated for cholangiocarcinoma? Am J Surg 1993; 166:768-772. Cross S.S., Variend S. Combined hepatoblastoma and yolk sac tumor of the liver. Cancer 1992; 69:1323- 1326. Ruck P., Keiserling E. Melanin-containing hepatoblastoma with endocrine differentiation. Cancer 1993; 72:361-368. Ruiz J., Sangro B., Cuende J.I., et al. Hepatitis B and C viral infections in patients with hepatocellular carcinoma. Hepatology 1992; 16:637-641. Gardiner G.W., Lajoie G., Keith R. Hepatoid adenocarcinoma of the papilla of Vater. Histopathology 1992; 20:541-544. Weihing R.R., Shintaku P.I., Geller S.A., et al. Hepatobiliary and pancreatic mucinous cystadenocarcinomas with mesenchymal stroma: analysis of estrogen and progesterone receptors and expression of tumor associated antigens. Mod Pathol 1997; 10:372-379. Rojter S.E., Villamil F.G., Petrovic L.M., et al. Malignant vascular tumors of the liver presenting as liver failure and portal hypertension. Liver Transplant Surg 1995; 1:156-161. Scoazec J.-Y., Degnott C., Reynes M., et al. Epithelioid hemangioendothelioma of the liver: an ultrastructural study. Hum Pathol 1989; 20:673-681. Leboit P.E., Berger T.G., Egbert B.M., et al. Bacillary angiomatosis: the histopathology and differential diagnosis of a pseudoneoplastic infection in patients with human immunodeficiency virus disease. Am J Surg Pathol 1989; 13:909-920. Marcelin A.G., Roque-Afonso A.M., Hurtova M., et al. Fatal disseminated Kaposi’s sarcoma following human herpesvirus 8 primary infections in livertransplant recipients. Liver Transpl 2004; 10:295- 300. Scheimberg I., Pollock D., Collins P., et al. Pathology of the liver in leukaemia and lymphoma. Histopathology 1995; 26:311-321. Page R.D., Romaguera J.E., Osborne B., et al. Primary hepatic lymphoma: favorable outcome after combination chemotherapy. Cancer 2001; 92:2023- 2029. Santos E.S., Raez L.E., Salvatierra J., et al. Primary hepatic non-Hodgkin’s lymphomas: case report and review of the literature. Am J Gastroenterol 2003; 98:2789-2793. Pirovino M., Jeaneret C., Lang R.H., et al. Liver cirrhosis in histiocytosis X. Liver 1988; 8:293-298. Alonso J.F., Saez C., Perez P., et al. Primary pure choriocarcinoma of the liver. Pathol Res Pract 1992; 188:375-377. Kondo Y., Wada K. Intrahepatic metastasis of hepatocellular carcinoma: a histopathologic study. Hum Pathol 1991; 22:125-130. |
Read_full_article: | pdf/21-2011/21-2-2011/SU21-2-2011Basa.pdf |
Correspondence: | Norina Basa, Municipal Hospital Timisoara, Romania |
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Article Title: | Primary and metastatic malignant tumors of the liver |
Authors: | Norina Basa1, Elena Lazăr2, Marioara Cornianu2, Alis Dema2, Sorina Tăban2, Daniela Lazăr3, Mirela Grigoraş2 |
Affiliation: | 1Municipal Hospital Timisoara, Romania; 2Department of Pathology Timisoara, Romania; 3Gastroenterology Clinic University of Medicine and Pharmacy “Victor Babeş” Timişoara, Romania |
Abstract: | The liver represents the most common localization of primary and metastatic hepatic tumors. This paper aims to review hepatic premalignant lesions and the histopathological classification of malignant tumors of the liver, describing the main growth patterns, citoarchitectural features and immunohistochemical profile of epithelial and mesenchymal hepatic tumors. Clinical aspects, differential diagnosis criteria and developmental-prognostic behavior are discussed. |
Keywords: | hepatic tumors, hepatocellular carcinoma, immunohistochemisty, Hep Par-1, α-fetoprotein |
References: | Anthony P.P. Tumors and tumor-like lesions of the liver and biliary tract. In: MacSween R.N.M., Anthony P.P., Scheuer P.J., et al., eds. Pathology of the liver, 4th ed. Edinburgh:Churchill Livingstone, 2002. De Souza A., Yamada T., Mills J.J., et al. Imprinted genes in liver carcinogenesis. FASEB J 1997; 11:60-67. Stuart K.E., Anand A.J., Jenkins R.L. Hepatocellular carcinoma in the United States: prognostic features, treatment outcome and survival. Cancer 1996; 77:2217-2222. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995; 22:983- 993. Ishak K.G., Anthony P.P., Sobin L.H. Histological typing of tumors of the liver. In:World Health Organization international histological classification of tumors, 2nd ed. Berlin: Springer-Verlag, 1994. Subramony C., Herrera G.A., Lockard V. Neuroendocrine differentiation in hepatic neoplasms: report of four cases. Surg Pathol 1993; 5:17-33. Lau S., Prakash S., Geller S.A., et al. Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma and metastatic adenocarcinoma. Hum Pathol 2002; 33:1175-1181. Craig J.R., Peters R.L., Edmondson H.A. Tumors of the liver and intrahepatic bile ducts. In: Atlas of tumor pathology, 2nd series, fascicle 26. Washington D.C: Armed Forces Institute of Pathology, 1989. Haratake J., Horie A. An immunohistochemical study of sarcomatoid liver carcinomas. Cancer 1991; 68:93-97. Hood D.L., Bauer T.W., Leibel S.A., et al. Hepatic giant cell carcinoma. An ultrastructural and immunohistochemical study. Am J Clin Pathol 1990; 93:111-116. LeBrun D.P., Silver M.M., Freedman M.H., et al. Fibrolamellar carcinoma of the liver in a patient with Fanconi anemia. Hum Pathol 1991; 22:396- 398. Ma C.K., Zarbo R.J., Frierson H.F., et al. Comparative immunohistochemical study of primary and metastatic carcinomas of the liver. Am J Clin Pathol 1993; 99:551-557. Ljubimova J.Y., Petrovic L.M., Wilson S.E., et al. Gene expression of HGF, its receptor (c-met), c-myc and albumin in cirrhotic and neoplastic human liver tissue. J Histochem Cytochem 1997; 45:79-87. Ojanguren I., Ariza A., Llatos M., et al. Proliferating cell nuclear antigen in normal, regenerative and neoplastic liver. Hum Pathol 1993; 24:905-908. An C., Petrovic L.M., Reyter I., et al. The application of neutal network technology to the study of large cell dysplasia and hepatocellular carcinoma. Hepatology 1997; 26:1224-1231. Wanless I., Callea F., Craig J., et al. Terminology of nodular lesions of the liver. Hepatology 1995; 25:983-993. Natarajan S., Theise N.D., Thung S.N., et al. Large-cell change of hepatocytes in cirrhosis may present a reaction to prolonged cholestasis. Am J Surg Pathol 1997; 21:312-318. Su Q., Benner A., Hofmann W.J., et al. Human hepatic preneoplasia: phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia. Virchows Arch 1997; 431:391-406. Ishak K.G., Goodman Z.D., Stocker J.T. Tumors of the liver and intrahepatic bile ducts. Armed Forces Institute of Pathology, Washington DC 2001; 9-48. Ferrell L. Hepatocellular nodules in the cirrhotic liver: diagnostic features and proposed nomenclature. In: Ferrell L. (ed.) Diagnostic problems in liver pathology. Pathology: state of the art reviews. Hanley & Belfus, Philadelphia 1994; 105-117. Ferrell L., Crawford J., Dhillon A., et al. Proposal for standardized criteria for the diagnosis of benign, borderline and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 1993; 17:1113-1123. Koneru B., Flye M.W., Busuttil R.W., et al. Liver transplantation for hepatoblastoma: the American Experience. Ann Surg 1991; 213:118-121. Wakely P.E. Jr., Silverman J.F., Geisinger K.R., et al. Fine needle aspiration biopsy cytology of hepatoblastoma. Mod Pathol 1990; 3:688-693. Goldstein R.M., Stona M., Tillery G.W., et al. Is liver transplantation indicated for cholangiocarcinoma? Am J Surg 1993; 166:768-772. Cross S.S., Variend S. Combined hepatoblastoma and yolk sac tumor of the liver. Cancer 1992; 69:1323- 1326. Ruck P., Keiserling E. Melanin-containing hepatoblastoma with endocrine differentiation. Cancer 1993; 72:361-368. Ruiz J., Sangro B., Cuende J.I., et al. Hepatitis B and C viral infections in patients with hepatocellular carcinoma. Hepatology 1992; 16:637-641. Gardiner G.W., Lajoie G., Keith R. Hepatoid adenocarcinoma of the papilla of Vater. Histopathology 1992; 20:541-544. Weihing R.R., Shintaku P.I., Geller S.A., et al. Hepatobiliary and pancreatic mucinous cystadenocarcinomas with mesenchymal stroma: analysis of estrogen and progesterone receptors and expression of tumor associated antigens. Mod Pathol 1997; 10:372-379. Rojter S.E., Villamil F.G., Petrovic L.M., et al. Malignant vascular tumors of the liver presenting as liver failure and portal hypertension. Liver Transplant Surg 1995; 1:156-161. Scoazec J.-Y., Degnott C., Reynes M., et al. Epithelioid hemangioendothelioma of the liver: an ultrastructural study. Hum Pathol 1989; 20:673-681. Leboit P.E., Berger T.G., Egbert B.M., et al. Bacillary angiomatosis: the histopathology and differential diagnosis of a pseudoneoplastic infection in patients with human immunodeficiency virus disease. Am J Surg Pathol 1989; 13:909-920. Marcelin A.G., Roque-Afonso A.M., Hurtova M., et al. Fatal disseminated Kaposi’s sarcoma following human herpesvirus 8 primary infections in livertransplant recipients. Liver Transpl 2004; 10:295- 300. Scheimberg I., Pollock D., Collins P., et al. Pathology of the liver in leukaemia and lymphoma. Histopathology 1995; 26:311-321. Page R.D., Romaguera J.E., Osborne B., et al. Primary hepatic lymphoma: favorable outcome after combination chemotherapy. Cancer 2001; 92:2023- 2029. Santos E.S., Raez L.E., Salvatierra J., et al. Primary hepatic non-Hodgkin’s lymphomas: case report and review of the literature. Am J Gastroenterol 2003; 98:2789-2793. Pirovino M., Jeaneret C., Lang R.H., et al. Liver cirrhosis in histiocytosis X. Liver 1988; 8:293-298. Alonso J.F., Saez C., Perez P., et al. Primary pure choriocarcinoma of the liver. Pathol Res Pract 1992; 188:375-377. Kondo Y., Wada K. Intrahepatic metastasis of hepatocellular carcinoma: a histopathologic study. Hum Pathol 1991; 22:125-130. |
*Correspondence: | Norina Basa, Municipal Hospital Timisoara, Romania |