Primary and metastatic malignant tumors of the liver

Primary and metastatic malignant tumors of the liver

This is an automatically generated default intro template – please do not edit.


General information


Title: Primary and metastatic malignant tumors of the liver
Meta keywords:
Meta description:

Images information


Images path absolute: /home/studia/public_html/v15/images/stories/com_form2content/p3/f92
Images path relative: com_form2content/p3/f92
Thumbs path absolute:
Thumbs path relative:

Fields information


Article_Title: Primary and metastatic malignant tumors of the liver
Authors: Norina Basa1, Elena Lazăr2, Marioara Cornianu2, Alis Dema2, Sorina Tăban2, Daniela Lazăr3, Mirela Grigoraş2
Affiliation: 1Municipal Hospital Timisoara, Romania;
2Department of Pathology Timisoara, Romania;
3Gastroenterology Clinic University of Medicine and Pharmacy “Victor Babeş” Timişoara, Romania
Abstract: The liver represents the most common localization of primary and metastatic hepatic tumors. This paper aims to review hepatic premalignant lesions and the histopathological classification of malignant tumors of the liver, describing the main growth patterns, citoarchitectural features and immunohistochemical profile of epithelial and mesenchymal hepatic tumors. Clinical aspects, differential diagnosis criteria and developmental-prognostic behavior are discussed.
Keywords: hepatic tumors, hepatocellular carcinoma, immunohistochemisty, Hep Par-1, α-fetoprotein
References: Anthony P.P. Tumors and tumor-like lesions of the liver
and biliary tract. In: MacSween R.N.M., Anthony
P.P., Scheuer P.J., et al., eds. Pathology of the liver,
4th ed. Edinburgh:Churchill Livingstone, 2002.
De Souza A., Yamada T., Mills J.J., et al. Imprinted genes
in liver carcinogenesis. FASEB J 1997; 11:60-67.
Stuart K.E., Anand A.J., Jenkins R.L. Hepatocellular
carcinoma in the United States: prognostic features,
treatment outcome and survival. Cancer 1996;
77:2217-2222.
International Working Party. Terminology of nodular
hepatocellular lesions. Hepatology 1995; 22:983-
993.
Ishak K.G., Anthony P.P., Sobin L.H. Histological typing
of tumors of the liver. In:World Health Organization
international histological classification of tumors,
2nd ed. Berlin: Springer-Verlag, 1994.
Subramony C., Herrera G.A., Lockard V. Neuroendocrine
differentiation in hepatic neoplasms: report of four
cases. Surg Pathol 1993; 5:17-33.
Lau S., Prakash S., Geller S.A., et al. Comparative
immunohistochemical profile of hepatocellular
carcinoma, cholangiocarcinoma and metastatic
adenocarcinoma. Hum Pathol 2002; 33:1175-1181.
Craig J.R., Peters R.L., Edmondson H.A. Tumors of the
liver and intrahepatic bile ducts. In: Atlas of tumor
pathology, 2nd series, fascicle 26. Washington D.C:
Armed Forces Institute of Pathology, 1989.
Haratake J., Horie A. An immunohistochemical study
of sarcomatoid liver carcinomas. Cancer 1991;
68:93-97.
Hood D.L., Bauer T.W., Leibel S.A., et al. Hepatic
giant cell carcinoma. An ultrastructural and
immunohistochemical study. Am J Clin Pathol
1990; 93:111-116.
LeBrun D.P., Silver M.M., Freedman M.H., et al.
Fibrolamellar carcinoma of the liver in a patient
with Fanconi anemia. Hum Pathol 1991; 22:396-
398.
Ma C.K., Zarbo R.J., Frierson H.F., et al. Comparative
immunohistochemical study of primary and
metastatic carcinomas of the liver. Am J Clin Pathol
1993; 99:551-557.
Ljubimova J.Y., Petrovic L.M., Wilson S.E., et al. Gene
expression of HGF, its receptor (c-met), c-myc and
albumin in cirrhotic and neoplastic human liver
tissue. J Histochem Cytochem 1997; 45:79-87.
Ojanguren I., Ariza A., Llatos M., et al. Proliferating
cell nuclear antigen in normal, regenerative and
neoplastic liver. Hum Pathol 1993; 24:905-908.
An C., Petrovic L.M., Reyter I., et al. The application of
neutal network technology to the study of large cell
dysplasia and hepatocellular carcinoma. Hepatology
1997; 26:1224-1231.
Wanless I., Callea F., Craig J., et al. Terminology of
nodular lesions of the liver. Hepatology 1995;
25:983-993.
Natarajan S., Theise N.D., Thung S.N., et al. Large-cell
change of hepatocytes in cirrhosis may present a
reaction to prolonged cholestasis. Am J Surg Pathol
1997; 21:312-318.
Su Q., Benner A., Hofmann W.J., et al. Human hepatic
preneoplasia: phenotypes and proliferation kinetics
of foci and nodules of altered hepatocytes and their
relationship to liver cell dysplasia. Virchows Arch
1997; 431:391-406.
Ishak K.G., Goodman Z.D., Stocker J.T. Tumors of
the liver and intrahepatic bile ducts. Armed Forces
Institute of Pathology, Washington DC 2001; 9-48.
Ferrell L. Hepatocellular nodules in the cirrhotic liver:
diagnostic features and proposed nomenclature.
In: Ferrell L. (ed.) Diagnostic problems in liver
pathology. Pathology: state of the art reviews.
Hanley & Belfus, Philadelphia 1994; 105-117.
Ferrell L., Crawford J., Dhillon A., et al. Proposal for
standardized criteria for the diagnosis of benign,
borderline and malignant hepatocellular lesions
arising in chronic advanced liver disease. Am J Surg
Pathol 1993; 17:1113-1123.
Koneru B., Flye M.W., Busuttil R.W., et al. Liver
transplantation for hepatoblastoma: the American
Experience. Ann Surg 1991; 213:118-121.
Wakely P.E. Jr., Silverman J.F., Geisinger K.R., et
al. Fine needle aspiration biopsy cytology of
hepatoblastoma. Mod Pathol 1990; 3:688-693.
Goldstein R.M., Stona M., Tillery G.W., et al. Is liver
transplantation indicated for cholangiocarcinoma?
Am J Surg 1993; 166:768-772.
Cross S.S., Variend S. Combined hepatoblastoma and
yolk sac tumor of the liver. Cancer 1992; 69:1323-
1326.
Ruck P., Keiserling E. Melanin-containing
hepatoblastoma with endocrine differentiation.
Cancer 1993; 72:361-368.
Ruiz J., Sangro B., Cuende J.I., et al. Hepatitis B and
C viral infections in patients with hepatocellular
carcinoma. Hepatology 1992; 16:637-641.
Gardiner G.W., Lajoie G., Keith R. Hepatoid
adenocarcinoma of the papilla of Vater.
Histopathology 1992; 20:541-544.
Weihing R.R., Shintaku P.I., Geller S.A., et al.
Hepatobiliary and pancreatic mucinous
cystadenocarcinomas with mesenchymal stroma:
analysis of estrogen and progesterone receptors
and expression of tumor associated antigens. Mod
Pathol 1997; 10:372-379.
Rojter S.E., Villamil F.G., Petrovic L.M., et al. Malignant
vascular tumors of the liver presenting as liver
failure and portal hypertension. Liver Transplant
Surg 1995; 1:156-161.
Scoazec J.-Y., Degnott C., Reynes M., et al. Epithelioid
hemangioendothelioma of the liver: an ultrastructural
study. Hum Pathol 1989; 20:673-681.
Leboit P.E., Berger T.G., Egbert B.M., et al. Bacillary
angiomatosis: the histopathology and differential
diagnosis of a pseudoneoplastic infection in patients
with human immunodeficiency virus disease. Am J
Surg Pathol 1989; 13:909-920.
Marcelin A.G., Roque-Afonso A.M., Hurtova M., et
al. Fatal disseminated Kaposi’s sarcoma following
human herpesvirus 8 primary infections in livertransplant
recipients. Liver Transpl 2004; 10:295-
300.
Scheimberg I., Pollock D., Collins P., et al. Pathology
of the liver in leukaemia and lymphoma.
Histopathology 1995; 26:311-321.
Page R.D., Romaguera J.E., Osborne B., et al. Primary
hepatic lymphoma: favorable outcome after
combination chemotherapy. Cancer 2001; 92:2023-
2029.
Santos E.S., Raez L.E., Salvatierra J., et al. Primary
hepatic non-Hodgkin’s lymphomas: case report and
review of the literature. Am J Gastroenterol 2003;
98:2789-2793.
Pirovino M., Jeaneret C., Lang R.H., et al. Liver cirrhosis
in histiocytosis X. Liver 1988; 8:293-298.
Alonso J.F., Saez C., Perez P., et al. Primary pure
choriocarcinoma of the liver. Pathol Res Pract 1992;
188:375-377.
Kondo Y., Wada K. Intrahepatic metastasis of
hepatocellular carcinoma: a histopathologic study.
Hum Pathol 1991; 22:125-130.
Read_full_article: pdf/21-2011/21-2-2011/SU21-2-2011Basa.pdf
Correspondence: Norina Basa, Municipal Hospital Timisoara, Romania

Read full article
Article Title: Primary and metastatic malignant tumors of the liver
Authors: Norina Basa1, Elena Lazăr2, Marioara Cornianu2, Alis Dema2, Sorina Tăban2, Daniela Lazăr3, Mirela Grigoraş2
Affiliation: 1Municipal Hospital Timisoara, Romania;
2Department of Pathology Timisoara, Romania;
3Gastroenterology Clinic University of Medicine and Pharmacy “Victor Babeş” Timişoara, Romania
Abstract: The liver represents the most common localization of primary and metastatic hepatic tumors. This paper aims to review hepatic premalignant lesions and the histopathological classification of malignant tumors of the liver, describing the main growth patterns, citoarchitectural features and immunohistochemical profile of epithelial and mesenchymal hepatic tumors. Clinical aspects, differential diagnosis criteria and developmental-prognostic behavior are discussed.
Keywords: hepatic tumors, hepatocellular carcinoma, immunohistochemisty, Hep Par-1, α-fetoprotein
References: Anthony P.P. Tumors and tumor-like lesions of the liver
and biliary tract. In: MacSween R.N.M., Anthony
P.P., Scheuer P.J., et al., eds. Pathology of the liver,
4th ed. Edinburgh:Churchill Livingstone, 2002.
De Souza A., Yamada T., Mills J.J., et al. Imprinted genes
in liver carcinogenesis. FASEB J 1997; 11:60-67.
Stuart K.E., Anand A.J., Jenkins R.L. Hepatocellular
carcinoma in the United States: prognostic features,
treatment outcome and survival. Cancer 1996;
77:2217-2222.
International Working Party. Terminology of nodular
hepatocellular lesions. Hepatology 1995; 22:983-
993.
Ishak K.G., Anthony P.P., Sobin L.H. Histological typing
of tumors of the liver. In:World Health Organization
international histological classification of tumors,
2nd ed. Berlin: Springer-Verlag, 1994.
Subramony C., Herrera G.A., Lockard V. Neuroendocrine
differentiation in hepatic neoplasms: report of four
cases. Surg Pathol 1993; 5:17-33.
Lau S., Prakash S., Geller S.A., et al. Comparative
immunohistochemical profile of hepatocellular
carcinoma, cholangiocarcinoma and metastatic
adenocarcinoma. Hum Pathol 2002; 33:1175-1181.
Craig J.R., Peters R.L., Edmondson H.A. Tumors of the
liver and intrahepatic bile ducts. In: Atlas of tumor
pathology, 2nd series, fascicle 26. Washington D.C:
Armed Forces Institute of Pathology, 1989.
Haratake J., Horie A. An immunohistochemical study
of sarcomatoid liver carcinomas. Cancer 1991;
68:93-97.
Hood D.L., Bauer T.W., Leibel S.A., et al. Hepatic
giant cell carcinoma. An ultrastructural and
immunohistochemical study. Am J Clin Pathol
1990; 93:111-116.
LeBrun D.P., Silver M.M., Freedman M.H., et al.
Fibrolamellar carcinoma of the liver in a patient
with Fanconi anemia. Hum Pathol 1991; 22:396-
398.
Ma C.K., Zarbo R.J., Frierson H.F., et al. Comparative
immunohistochemical study of primary and
metastatic carcinomas of the liver. Am J Clin Pathol
1993; 99:551-557.
Ljubimova J.Y., Petrovic L.M., Wilson S.E., et al. Gene
expression of HGF, its receptor (c-met), c-myc and
albumin in cirrhotic and neoplastic human liver
tissue. J Histochem Cytochem 1997; 45:79-87.
Ojanguren I., Ariza A., Llatos M., et al. Proliferating
cell nuclear antigen in normal, regenerative and
neoplastic liver. Hum Pathol 1993; 24:905-908.
An C., Petrovic L.M., Reyter I., et al. The application of
neutal network technology to the study of large cell
dysplasia and hepatocellular carcinoma. Hepatology
1997; 26:1224-1231.
Wanless I., Callea F., Craig J., et al. Terminology of
nodular lesions of the liver. Hepatology 1995;
25:983-993.
Natarajan S., Theise N.D., Thung S.N., et al. Large-cell
change of hepatocytes in cirrhosis may present a
reaction to prolonged cholestasis. Am J Surg Pathol
1997; 21:312-318.
Su Q., Benner A., Hofmann W.J., et al. Human hepatic
preneoplasia: phenotypes and proliferation kinetics
of foci and nodules of altered hepatocytes and their
relationship to liver cell dysplasia. Virchows Arch
1997; 431:391-406.
Ishak K.G., Goodman Z.D., Stocker J.T. Tumors of
the liver and intrahepatic bile ducts. Armed Forces
Institute of Pathology, Washington DC 2001; 9-48.
Ferrell L. Hepatocellular nodules in the cirrhotic liver:
diagnostic features and proposed nomenclature.
In: Ferrell L. (ed.) Diagnostic problems in liver
pathology. Pathology: state of the art reviews.
Hanley & Belfus, Philadelphia 1994; 105-117.
Ferrell L., Crawford J., Dhillon A., et al. Proposal for
standardized criteria for the diagnosis of benign,
borderline and malignant hepatocellular lesions
arising in chronic advanced liver disease. Am J Surg
Pathol 1993; 17:1113-1123.
Koneru B., Flye M.W., Busuttil R.W., et al. Liver
transplantation for hepatoblastoma: the American
Experience. Ann Surg 1991; 213:118-121.
Wakely P.E. Jr., Silverman J.F., Geisinger K.R., et
al. Fine needle aspiration biopsy cytology of
hepatoblastoma. Mod Pathol 1990; 3:688-693.
Goldstein R.M., Stona M., Tillery G.W., et al. Is liver
transplantation indicated for cholangiocarcinoma?
Am J Surg 1993; 166:768-772.
Cross S.S., Variend S. Combined hepatoblastoma and
yolk sac tumor of the liver. Cancer 1992; 69:1323-
1326.
Ruck P., Keiserling E. Melanin-containing
hepatoblastoma with endocrine differentiation.
Cancer 1993; 72:361-368.
Ruiz J., Sangro B., Cuende J.I., et al. Hepatitis B and
C viral infections in patients with hepatocellular
carcinoma. Hepatology 1992; 16:637-641.
Gardiner G.W., Lajoie G., Keith R. Hepatoid
adenocarcinoma of the papilla of Vater.
Histopathology 1992; 20:541-544.
Weihing R.R., Shintaku P.I., Geller S.A., et al.
Hepatobiliary and pancreatic mucinous
cystadenocarcinomas with mesenchymal stroma:
analysis of estrogen and progesterone receptors
and expression of tumor associated antigens. Mod
Pathol 1997; 10:372-379.
Rojter S.E., Villamil F.G., Petrovic L.M., et al. Malignant
vascular tumors of the liver presenting as liver
failure and portal hypertension. Liver Transplant
Surg 1995; 1:156-161.
Scoazec J.-Y., Degnott C., Reynes M., et al. Epithelioid
hemangioendothelioma of the liver: an ultrastructural
study. Hum Pathol 1989; 20:673-681.
Leboit P.E., Berger T.G., Egbert B.M., et al. Bacillary
angiomatosis: the histopathology and differential
diagnosis of a pseudoneoplastic infection in patients
with human immunodeficiency virus disease. Am J
Surg Pathol 1989; 13:909-920.
Marcelin A.G., Roque-Afonso A.M., Hurtova M., et
al. Fatal disseminated Kaposi’s sarcoma following
human herpesvirus 8 primary infections in livertransplant
recipients. Liver Transpl 2004; 10:295-
300.
Scheimberg I., Pollock D., Collins P., et al. Pathology
of the liver in leukaemia and lymphoma.
Histopathology 1995; 26:311-321.
Page R.D., Romaguera J.E., Osborne B., et al. Primary
hepatic lymphoma: favorable outcome after
combination chemotherapy. Cancer 2001; 92:2023-
2029.
Santos E.S., Raez L.E., Salvatierra J., et al. Primary
hepatic non-Hodgkin’s lymphomas: case report and
review of the literature. Am J Gastroenterol 2003;
98:2789-2793.
Pirovino M., Jeaneret C., Lang R.H., et al. Liver cirrhosis
in histiocytosis X. Liver 1988; 8:293-298.
Alonso J.F., Saez C., Perez P., et al. Primary pure
choriocarcinoma of the liver. Pathol Res Pract 1992;
188:375-377.
Kondo Y., Wada K. Intrahepatic metastasis of
hepatocellular carcinoma: a histopathologic study.
Hum Pathol 1991; 22:125-130.
*Correspondence: Norina Basa, Municipal Hospital Timisoara, Romania