Assessment of the effects of ibuprofen association with nifedipine on ibuprofen induced hepatotoxicity

Authors: Răzvan GLIGOR¹*, Şerban GLIGOR²

Affiliation: ¹ “Vasile Goldiş” Western University Arad, Romania; ² West University Timişoara, Romania

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ABSTRACT. Ibuprofen is a nonsteroidal anti-inflammatory drug with large clinical applications, which implies its co-administration with different other medicines, to patients with a complex morbidity. A major unwanted consequences following ibuprofen administration in patients is its liver toxicity. We’ve studied the consequences of the co-administration of ibuprofen with nifedipine, a calcium channel blocker, aiming the finding of novel medicines associations for optimizing the ibuprofen therapy and reducing its liver toxicity. Following these investigations we found out the association of nifedipine to ibuprofen therapy offers no significant protections against the hepatic injuries induced by ibuprofen. The experimental results we’ve obtained suggests that the excess of calcium ions plays no role in the ibuprofen induced hepatotoxicity, so that other causes might be involved in producing these lesions.

Keywords: ibuprofen, nifedipine, hepatotoxicity, hepato-protecting effect