The antioxidant role of selenium in preventing nickel-related kidney damage in rats
December 26, 2024
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| Article Title: | The antioxidant role of selenium in preventing nickel-related kidney damage in rats |
| Authors: | Saker H., Gasmi S., Benkhedir A., Boussekine S. |
| Affiliation: | University of Tebessa, Faculty of Sciences and Natural and Life Sciences, Tebessa, 12000, Algeria University of Tissemsilt, Tissemsilt, 38000, Algeria |
| Abstract: | The aim of this study is to examine the protective and antioxidant effects of selenium on nickel-induced oxidative stress in male albino Wistar rats. For this purpose, 28 male albino Wistar rats of similar age and body weight were divided into four groups. The first group served as the control, the second group received only selenium with 2 mg/kg/day orally, the third group received only nickel with a dose of 10 mg/kg/day orally gavage, and the fourth exposure both selenium and nickel. The rats were monitored for four weeks to observe any changes in their kidney function and antioxidant activity. The results of the study showed that selenium had a protective effect against nickel-induced nephrotoxicity in male albino Wistar rats. Selenium was found to reduce the levels of oxidative stress markers, such as malondialdehyde and glutathione, as well as increasing the activity of antioxidant enzymes, such as superoxide dismutase and catalase. The results also showed that selenium had a protective effect against nickel-induced nephrotoxicity in male albino Wistar rats, as evidenced by an increase in the levels of creatinine, urea, and uric acid. Overall, this study suggests that selenium supplementation can protect against nickel-induced nephrotoxicity in male albino Wistar rats. Selenium has been found to reduce the levels of oxidative stress markers and increase the activity of antioxidant enzymes, thus protecting against oxidative damage. Therefore, selenium may be a useful supplement in preventing nephrotoxicity caused by nickel. |
| Keywords: | oxidative stress, antioxidant, renal function, nickel, selenium, rat. |
| *Correspondence: | Dr. Salim Gasmi, University of Tebessa, Faculty of Sciences and Natural and Life Sciences, Tebessa, Algeria, Tel: (+213)673203709, email: Salim.gasmi@univ-tebessa.dz. |
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