Immunoexpression of P53, IDH1 and ATRX in gliomas
February 20, 2024
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| Article Title: | Immunoexpression of P53, IDH1 and ATRX in gliomas |
| Authors: | Khireddine L., Bouchemal A.,Ghidouche A., Tliba S., Bedjou F. |
| Affiliation: | Université de Bejaia, Faculté des Sciences de la Nature et de la Vie, Laboratoire de Biotechnologies Végétales et Ethnobotanique, Bejaia, Algérie Université de Bejaia, Laboratoire de Geni-biologique des cancers, Bejaia, Algérie Service de Neurochirurgie, Centre hospitalo-universitaire, Bejaia, Algérie Université de Bejaia, Faculté de Medecine, Bejaia, Algérie |
| Abstract: | Gliomas account for 45% of all intracranial tumors. Technologies, allowed better molecular analysis leading to the discovery of IDH1 (Isocitrate dehydrogenase) mutations. IDH1 mutations are often associated with ATRX (alphathalassemia/mental retardation syndrome Xlinked) and P53. In this study, we analyzed their expression and correlation with grade. 28 samples were included in the study. Immunohistochemistry for IDH1, ATRX, and P53 was done and reported. Statistical analysis was done in order to compare their immunoexpression in different grades of gliomas. A total of 28 gliomas were included, excluding pilocytic astrocytoma. IDH1, ATRX, and P53 positivity was seen in both Diffuse glioma and Glioblastoma, at almost the same frequencies. A combined analysis of expression of IDH1 and ATRX, and P53 with WHO grade showed statistically no significant association. Neither IDH1, ATRX, and P53 immunoexpression nor their combination at two and three variants showed significant differences according to the grade in this study. |
| Keywords: | glioblastoma, diffuse gliomas, immunohistochemistry, grade, profile |
| *Correspondence: | Khireddine Lydia, Université de Bejaia, Faculté des Sciences de la Nature et de la Vie, Laboratoire de Biotechnologies Végétales et Ethnobotanique, 06000 Bejaia Algérie. Email: khireddinelydia@gmail.com. |
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