Studies on the formulation of nanostructured carriers for increasing the bioavailability of Pralidoxime Chloride

November 17, 2014

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Article Title:	Studies on the formulation of nanostructured carriers for increasing the bioavailability of Pralidoxime Chloride
Authors:	Orbesteanu A-M, Cojocaru V., Ailiesei I., Mircioiu C.,Cinteza L.O.
Affiliation:	1 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest 2Faculty of Chemistry, University of Bucharest
Abstract:	The life threatening intoxication with highly toxic organophosphorous nerve agents requires the immediate administration of antidotes such as oximes. For the standard treatment of this intoxication, pralidoxime chloride (PAM) proved to be one of the most important antidotes. This study focused on the formulation of modern colloidal vectors for the delivery of pralidoxime chloride, such as liposomes and cubosomes. Taking into consideration the fact that this drug owns a low bioavailability, due to its high hydrophilicity, the formulation aimed at improving this behaviour.
Keywords:	nanotechnology, liposomes, cubosomes, oximes, pralidoxime chloride
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*Correspondence:	Orbesteanu Ana-Maria, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; e-mail: anaorbesteanu@yahoo.ro