Cytotoxic effect of SNO2 nanoparticles on alternative cellular model: Paramecium tetraurelia
November 17, 2014
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| Article Title: | Cytotoxic effect of SNO2 nanoparticles on alternative cellular model: Paramecium tetraurelia |
| Authors: | Bouarroudj T., Rida Benloucif M., Mekki D.E., Djekoun M., Benamara M., Berrebbeh H. |
| Affiliation: | 1Laboratory of Chemistry of Inorganic Materials, Department of Chemistry, Badji Mokhtar University, Annaba, Algeria 2Laboratory of Study of Surfaces and Interfaces of the Solid Matter, Department of Physic, Badji Mokhtar University, Annaba, Algeria 3Laboratory of Cellular Toxicology, Department of Biology, Badji Mokhtar University, Annaba, Algeria |
| Abstract: | The development of nanotechnologies and their uses, leads to an increase of nanoparticles concentrations in the air, water and soil. For better understanding the potential impacts of metal oxide nanoparticles in the ecosystem, the present study investigates the cytotoxic effect of SnO2 nanoparticles for different grain sizes on the alternative model of freshwater, water pollution bioindicator, Paramecium tetraurelia. The size of SnO2 nanometric powder (Sigma-Aldrich 99.99% pure) has been reduced using mechanical milling with different times. Obtained nanomaterials were then characterized by X-ray diffraction (XRD) and spectroscopy infrared Fourier transforms (FTIR). Moreover, the toxicity of SnO2 nanoparticles on paramecium was studied by following the evolution of the growth kinetics and percent response as a function of time; whereas the impact of SnO2 nanoparticles on paramecium was determined on two biomarkers of oxidative stress respectively, Catalase (CAT) and glutathione S-transferase (GST). The preliminary results show a non-negligible effect of SnO2 (NPs) via their grain sizes. Indeed, it was recorded an increase in the number of paramecium at low concentrations of SnO2 and its inhibition at high concentrations. |
| Keywords: | Nanoparticles, SnO2, grain size, Paramecium tetraurelia, cytotoxicity. |
| *Correspondence: | Tayeb BOUARROUDJ, Department of Chemistry, Badji Mokhtar University, BP 12, 23000 Annaba, Algeria,email:bouarroudj.tayeb@gmail.com |
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