In vitro evaluation of semisolid topical formulations containing organometallic complexes of Copper and Cobalt with oxicams
November 17, 2014
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| Article Title: | In vitro evaluation of semisolid topical formulations containing organometallic complexes of Copper and Cobalt with oxicams | ||
| Authors: | Tudosa C-P, Lupuleasa D., Mitu M.A., Hîncu L., Rădulescu F.Ș., Miron D.S. | ||
| Affiliation: | University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, no.6 Traian Vuia St., 020956, Bucharest, Romania. 1Department of Drug Industry and Pharmaceutical Biotechnologies, 2Department of Pharmaceutical Technology and Biopharmaceutics, 3Department of Pharmaceutical Physics and Informatics. | ||
| Abstract: | The paper presents the results of correlated in vitro release and rheological assessment of hydrophilic gels containing organometallic complexes of copper and cobalt with piroxicam and tenoxicam. The semisolid experimental formulations intended for local delivery after application onto the skin were prepared based on polyoxyethylene-polyoxypropylene copolymers (Poloxamer 407). The results confirmed that the diffusion process of the hydrophobic compounds had long lag-times and release rates depending upon the affinity of the complex for the semisolid matrix. Higher consistency due to particular internal interactions generated decreased release rates. All formulations presented a pseudoplastic behavior, adequately described by Ostwald de Waele model. | ||
| Keywords: | organometallic complexes, cobalt, copper, oxicam ligand, in vitro release, hydrogels. | ||
| *Correspondence: | Mirela Adriana Mitu, University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, no.6 Traian Vuia St., 020956, Bucharest, Romania, Tel. +40-(21)-3180740, email: mitumirela@gmail.com. |
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