Formulation and evaluation of lorazepam microemulsion for parenteral delivery system

November 17, 2014

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Article Title:	Formulation and evaluation of lorazepam microemulsion for parenteral delivery system
Authors:	Sayani Bhattacharyya1*,Renuka Priya Vuppalapati1
Affiliation:	1Dept of Pharmaceutics,The Oxford College of Pharmacy, Bangalore, India.
Abstract:	The objective of this investigation was to develop Lorazepam microemulsion without a cosolvent. Solubility of Lorazepam in various oils and Solutol HS 15 was determined. The ternary diagram was plotted to identify area of microemulsion existence and a suitable composition with Miglyol 810 and Solutol HS 15 was identified. Process variables like mixing speed and time were optimized.The lorazepam microemulsion was evaluated for globule size, zeta potential, polydispersity index, pH, in vitro haemolysis and stability study. Lorazepam microemulsion with Miglyol 810 and Solutol HS 15 showed optimum particle size negligible haemolysis and optimum stability
Keywords:	lorazepam, miglyol 810, solutol HS 15, microemulsion, stability.
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*Correspondence:	Sayani Bhattacharyya, Dept of Pharmaceutics, The Oxford College of Pharmacy, 6/9, IstCross , Hongasandra, Begur Road, Bangalore -560068, Tel :918030219831. sayanibh@gmail.com