Delivery of nebivolol hydrochloride from immediate release tablets

November 17, 2014

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Article Title:	Delivery of nebivolol hydrochloride from immediate release tablets
Authors:	Khalaf Z., Ardelean S., Drăgănescu D., Ardelean M., Lupuleasa D.
Affiliation:	1 „Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest 2„Vasile Goldiș” Western University of Arad, Faculty of Pharmacy, Arad, Romania
Abstract:	The paper presents the results of our study regarding 9 formulations with nebivolol 10 mg with immediate release. The solubility of nebivolol hydrochloride was determined in various aqueous solutions and buffer (HCl pH=2). The solubility study was conducted by taking excess amounts of the drug in solution. In vitro dissolution profiles showed a rapid release, approaching 10% of the declared content of nebivolol hydrochloride, towards the end of the test period.
Keywords:	nebivolol hydrochloride, immediate release tablets, dissolution tests, USP 34
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*Correspondence:	Doina Drăgănescu, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia St., Bucharest, Romania. Tel: +40-(21)-3180747, email: doinadraganescu@yahoo.com