Magnetic hyperthermia on mouse B16 melanoma using superparamagnetic nanoparticles

November 17, 2014

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Article Title:	Magnetic hyperthermia on mouse B16 melanoma using superparamagnetic nanoparticles
Authors:	Avram M., Volmer M., Tucureanu V., Avram A., Radoi A., Petrescu I.
Affiliation:	National Institute for Research and Development in Microtechnologies 126A Erou Iancu Nicolae Street, Bucharest, Romania Transilvania” University of Brasov 29 Eroilor Street, Brasov, Romania Department of Plastic Surgery and Reconstructive Microsurgery, Emergency University Hospital 169 Splaiul Independentei, Bucharest, Romania
Abstract:	This study examines the therapeutic antitumour effect of magnetic hyperthermia enhanced by γ-Fe2O3 superparamagnetic nanoparticles in B16 mouse melanoma. Therapeutic protocol consisted of two sessions of intravenous nanoparticle administration, followed by a local exposure to a magnetic field concentrator for 10 minutes and to an external alternating magnetic field (120 kHz and 18 mT) for 30 minutes, tumour being heated to 43°C. The results revealed a strong decrease in tumour volumes at the end of therapy, thus confirming the effectiveness of local magnetic hyperthermia. FTIR and Raman characterization after treatment revealed cellular apoptosis through the occurrence of the oxidative process in the tumoral tissues and the detection of the phosphatidylserine bond. The apoptosis of B16 melanoma cells was studied by FTIR and Raman spectrometry. The results clearly suggest the apoptosis of melanoma cells.
Keywords:	B16 mouse melanoma, apoptosis, magnetic hyperthermia, maghemite nanoparticles, FTIR spectroscopy.
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*Correspondence:	Marioara Avram., National Institute for Research and Development in Microtechnologies 126A Erou Iancu Nicolae Street, Bucharest, Romania

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