Human paraoxonase 1 (PON1) and its association with cardiovascular disease risk on a group study of young hypertensive patients

November 17, 2014

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Article Title:	Human paraoxonase 1 (PON1) and its association with cardiovascular disease risk on a group study of young hypertensive patients
Authors:	Popa C., Popescu C., Pilat L., Puşchiţă M.
Affiliation:	1Faculty of Medicine “Vasile Goldis” Western University of Arad Institute of Life Sciences “Vasile Goldis” Western University of Arad Emergency County Hospital of Arad
Abstract:	Introduction: The incidence of cardiovascular diseases is increasing every year in our country and hypertension population is leaning to younger ages and for that we need an effective medical tool for prevention. Aim: Our objective is to analyse atherogenic risk data for young hypertensive patients. Method: comparison of PON1 levels and atherogenic risk calculators on two hypertensive patients groups (20 newly-discovered hypertensive patients and 20 grade I hypertension patients) and a control group (15 subjects). Results: The AIP shows important atherogenic risk data with statistically importance for the second hypertensive group rather for the first hypertensive study group but the PON1 values are very relevant for all the groups. Conclusion: Determination of PON1 values may be a useful and effective quantification tool for cardiovascular disease risk if we take in consideration the results from our study which shows low levels of PON1 even in asymptomatic patients (control group and the first group of hypertensive patients).
Keywords:	PON1, human paraoxonase 1, hypertension, atherogenesis, cardiovascular risk, HDL-c, LDL-c, TC.
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*Correspondence:	Calin Popa, 37 George Cosbuc Street, Arad- Romania, Email: calinpopa@msn.com.Tel: +40722 247 246

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