Initial empiric antibiotic treatment in severe bacterial infections

November 17, 2014

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Article Title:	Initial empiric antibiotic treatment in severe bacterial infections
Authors:	Papagheorghe R.
Affiliation:	Central laboratory, Hospital Coltea, Bucharest, Romania
Abstract:	The progress of diagnosis means of infections, the improvement of surgical techniques and large spectre antibiotic availability resulted in an important reduction of the morbidity and mortality produced by severe bacterial infections (SBIs) in the last century. Nevertheless, this pathology remains a major challenge for surgeons, internists, infectious diseases and microbiology specialists. The adequacy of initial empiric antibiotic therapy is life-saving. Progressive bacterial resistance and its spread within institutions limit the antibiotic treatment options and the patients’ outcome. This phenomenon is more obvious in Gramnegative bacilli which are the main cause of SBIs in countries were the antibiotic treatment is based rather on general guidelines than on local susceptibility data. This presentation discusses criteria for choosing empiric antimicrobial therapy aiming to reduce the use of unnecessary anti -pseudomonas antibiotics and outlines available therapies for these infections.
Keywords:	bacterial infections, anti-pseudomonas antibiotics, multidrug resistant organisms
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*Correspondence:	Raluca Papagheorghe, Central laboratory, Hospital Coltea, Bucharest, Romania, email: r.papagheorghe@yahoo.com