Artichoke (Cynara scolymus L.) extracts are showing concentration-dependent hormetic and cytotoxic effects on breast cancer cell lines
November 17, 2014
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| Article Title: | Artichoke (Cynara scolymus L.) extracts are showing concentration-dependent hormetic and cytotoxic effects on breast cancer cell lines |
| Authors: | Vígh Sz., Zsvér-Vadas Zs., Pribac C., Moş L., Cziáky Z., Czapár M., Mihali C-V, Turcuş V., Máthé E. |
| Affiliation: | 1 University of Nyíregyháza, Institute of Agricultural Sciences, Nyíregyháza, Hungary, 2 University of Nyíregyháza, Agricultural and Molecular Research Institute, Nyíregyháza, Hungary 3 “Vasile Goldiş” Western University of Arad, Faculty of Medicine, Arad, Romania 4 University of Debrecen, Faculty of Agriculture and Food Sciences and Environmental Management, Debrecen, Hungary 5 “Vasile Goldiş” Western University of Arad, Institute of Life Scinces, Arad, Romania |
| Abstract: | Chemomapping of artichoke (Cynara scolymus L.) leaf extracts revealed novel bioactive compounds with putative anti-tumor effects, and therefore, we set to analyze the cytotoxic effects of aqueous and alcoholic extracts on T-47D and ZR-75-1 human breast cancer cell lines. A concentration dependent hormetic response was detected in the case of aqueous extract, while the alcoholic extract featured a pronounced cytotoxic effect as inferred by the MTT proliferation assays. Immunocytochemical analyses of treated cells were suggesting that the observed cytotoxicity could be associated with cellular senescence and/or apoptosis. Our experimental data are suggesting that the artichoke could be a good candidate for the complementary treatment of certain human cancers but further studies are needed to shed light on all aspects related to its hormetic dose response and cytotoxic effect not talking about the putative hepatoprotective effect in relation to cancer therapy efficiency. |
| Keywords: | artichoke, Cynara scolymus L., human breast cancer, hormesis, cytotoxicity |
| *Correspondence: | Endre Máthé Vasile Goldiş” Western University of Arad, Faculty of Medicine, Liviu Rebreanu Str.91-93, RO-310414, Arad, Romania, University of Nyíregyháza, Agricultural and Molecular Research Institute, Sóstói str. 31/B, H-4432, Nyíregyháza, Hungary, University of Debrecen, Faculty of Agriculture and Food Sciences and Environmental Management, Böszörményi str. 138, H-4032 Debrecen, Hungary, endre.mathe64@gmail.com |
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