The paracetamol and theophylline co-administration – an avoiding to interaction

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Article Title:	The paracetamol and theophylline co-administration – an avoiding to interaction
Authors:	Răzvan Gligor, Şerban Gligor
Affiliation:	”Vasile Goldis” Western University, Faculty of Medicine, Pharmacy and Dental Medicine, Medicine Department, Arad West University, Faculty of Physical Education and Sports, Kinesytherapy Department, Timisoara
Abstract:	This paper presents the consequences of Paracetamol and Theophylline co-administration in experimental conditions. For this purpose we used laboratory animals (rats) to whom a single intraperitonealy dose of theophylline (15 mg/kg body weight) has been administered 2 hours after receiving an overdose of paracetamol (1500 mg/kg body weight). Comparatively another xantine base, namely caffeine have been administered intraperitonealy (100 mg/kg body weight). Theophylline showed a high degree of toxicity, increased paracetamol hepatotoxicity, and mortality, perhaps because of generalized convulsions caused by theophylline free, active, in excess. Instead, caffeine significantly reduced the toxicity of paracetamol.
Keywords:	theophylline, paracetamol, co-administration, hepatotoxicity, caffeine
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*Correspondence:	Serban Gligor, MD, PhD, Lecturer, West University, Faculty of Physical Education and Sport, Kinesytherapy Department, Tel.+40256592.129, Fax.+40256592129, e-mail: gligor_serban@yahoo.com