Preparation and physicochemical characterization of poorly soluble drug-loaded lipid nanoparticles

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Article Title:	Preparation and physicochemical characterization of poorly soluble drug-loaded lipid nanoparticles
Authors:	Răzvan Prisada, Cristina Dinu Pîrvu, Mariana Ferdeş, Alina Orţan, Corina Dalia Toderescu, Dumitru Lupuliasa
Affiliation:	Physical and Colloidal Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest University Polytechnic Bucharest Analytical Chemistry Department, Faculty of Medicine, Pharmacy and Dental Medicine, ”Vasile Goldis” Western University, Arad, Romania Pharmaceutical Technology and Biopharmacy Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Abstract:	This study presents the preparation and characterization of testosterone loaded lipid nanoparticles in order to obtain a topical system. The designed lipid nanostructures were prepared by conventional rotary evaporation method followed by mechanical dispersion in hydrating medium or by the method proposed by Touitou. The effects of formulation variables upon the liposomes` characteristics were also investigated. The experiments showed that the molar ratios of the drug, PC and Co influence the drug entrapment or, in the two case, the entrapment efficiency was affected by the percentage of ethanol, PC and TS in the formulation. The stability of the lipid vesicles was determined by the entrapment efficiency and size distribution. The studies were performed during a period of 2 months. Lipid vesicles prepared by Touitou method proved to be more stable than the first, in the same experimental conditions.
Keywords:	lipid vesicles, topical application, entrapment efficiency, size distribution, stability
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*Correspondence:	Cristina Dinu Pîrvu, Colloidal and Physical Chemistry Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, no.6, Traian Vuia St., 020956, Tel. +40-(021)-3180751, Fax. +40-(021)-3180751, email: ecristinaparvu@yahoo.com