Arginine effects on in vivo glucose-induced insulin secretion in mice and hamsters

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Article Title:	Arginine effects on in vivo glucose-induced insulin secretion in mice and hamsters
Authors:	Ioana Trandaburu, Dorina Mirancea, Mirela Simionescu, Tiberiu Trandaburu
Affiliation:	1 Centre of Cytobiology, Institute of Biology, Bucharest 2 Laboratory of Histology and Embriology, Faculty of Sciences, University of Pitesti
Abstract:	Alterations of the biphasic pattern of insulin secretion and of glycemia induced with glucose were described for the first time in hamsters after the sole i.p. injection of a mixture of glucose (3,3 g glucose/kg body weight) and L-arginine (7,16g arginine/kg body weight) or after 10 min. delayed injections of identical amounts of the same hexose and amino acid . With the exception of several minor, species-specific differences, the monophasic hyperglycemic profiles evoked by both experimental variants pledge undoubtedly for a stimulatory effect of arginine on the glucose induced insulin secretion (time-dependent potentiation; TDP), much less expressed in mice than in hamsters. Taking into account, however, the quantitative fluctuations of the B-cells granular contents evinced histochemically is rather likely to presume the co-existence and successive exercise of both potentiation and inhibition states (TDP, TDI) of the glucose-induced insulin secretion in the two rodents species studied. The above results obtained “in vivo” are discussed in connection with the findings reported in other mammalian species.
Keywords:	in vivo time-course, insulin secretion and glycemia, arginine and glucose, mice and hamsters
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*Correspondence:	Ioana TRANDABURU, Institute of Biology, no. 296 Spl. Independenţei, 060031, Bucharest, e-mail: itrandaburu@yahoo.com; ioana.trandaburu@ibiol.ro