The role of androgen receptors for new therapeutic strategies and the prognostic outcome in patients with breast cancer

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Article Title:	The role of androgen receptors for new therapeutic strategies and the prognostic outcome in patients with breast cancer
Authors:	Diana Narita, George-Ciprian Pribac, Aurel Ardelean
Affiliation:	1 University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania 2 ”Vasile Goldis” Western University Arad, Romania
Abstract:	It has been suggested that AR could be prognostic markers for breast cancers but their role in the pathogenesis of breast carcinomas is far to be clear. The purpose of this study was to asses by immunohistochemistry the AR expression in female breast carcinomas and to correlate the results with the immunoexpression ER/PR status, HER2/neu status and some histopathological features of carcinomas, like histological type and grade, nodal and metastasis status. We have found a positive correlation between AR and the histological type of the tumor and the grade of differentiation, most of AR-positive carcinomas being well and moderate differentiated. A negative association was found between AR and the nodal status, the majorities of AR-positive cases being lymph node negative. We did not find a statistical significant correlation with HER2, ER/PR and metastasis status. We can conclude that AR could be useful for establishing new therapeutic strategies and for evaluating the prognostic outcome in patients with breast cancer.
Keywords:	breast cancer, estrogen receptors, progesterone receptors, androgen receptors, HER2/neu
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*Correspondence:	Diana Narita, Department of Biochemistry, University of Medicine and Pharmacy „Victor Babes” Timisoara, email: diana_narita@yahoo.com