Adrenal glands morpho-functional damages at wistar rats after chemotherapy administration
October 2, 2012
Adrenal glands morpho-functional damages at wistar rats after chemotherapy administration
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| Title: | Adrenal glands morpho-functional damages at wistar rats after chemotherapy administration |
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| Article_Title: | Adrenal glands morpho-functional damages at wistar rats after chemotherapy administration |
| Authors: | Anca Hermenean, Aurel Ardelean, Constantin Crăciun |
| Affiliation: | 1 Faculty of Medicine, “Vasile Goldiș” Western University, Arad, Romania 2 Electron Microscopy Center, “Babes-Bolyai” University, Cluj-Napoca, Arad, Romania |
| Abstract: | Most of cancer drugs used in chemotherapy induce most of the time strong immunosuppresive states and lymphotoxic effects, characterized especially by the alteration of lymphoid tissues. The aim of this study is to reveal stress conditions adrenals response after given chemotherapy as the connections between immune and endocrine system are well known. Giving 40 mg/kg body/day cyclophosphamide (CFA) therapy to rats by 3 days consecutively i.p. injections, can determine morphological and structural damages of the studied organs. The 24 hours adrenals histopathological and electron microscopy examination after CFA last dose administration proved the installations of some structural changes especially in the glomerulosa and fasciculata zone of adrenal cortex. |
| Keywords: | cyclophosphamide, adrenal glands morpho-functional damages |
| References: | Blank JA, Joiner RL, Houchens DP, Dill GS, Hobson DW. Comparative immunotoxicity of 2,2′- dichlorodiethyl sulfide and cyclophosphamide: evaluation of L1210 tumor cell resistance, cellmediated immunity, and humoral immunity.Int J Immunopharmacol.13(2-3):251-7, 1991 Giurgea R., Corelaţii endocrino-imunitare, Ed Risoprint, p. 166, 1994 Karp j, Szczytkowski J, Gentile C, Noradrenergic responses of peripheral organs to cyclophosphamide in mice, Life Science, Volume 75,Issue 17, pp. 2077-2089, 2004 Luster M, Portier C, Pait D, Rosenthal G, Germolec D, Corsini E, Blaylock B, Pollock P, Kouchi Y, Craig W. Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests. Fundam Appl Toxicol. 21 (1):71-82, 1993 Paşca C., Crăciun C., Ardelean A., Efecte secundare ale unor citostatice asupra organismului, Ed. Risoprint, Cluj-Napoca, p. 307, 2000 Paşca C., Miclăuş V., Ardelean A., Kis E., Sandu D., Crăciun V., papuc I., Structural and ultrastructural aspects of the rat thymus after carboplatin chemotherapy, Current Problems in Cellular and Molecular Biology, vol.V, C.Crăciun, A.Ardelean editors, Ed.Risoprint Cluj-Napoca, pp. 276-284, 2000 Shigeru Shibata , Masahiro Kami , Yoshinobu Kanda , Utako Machida , Hiroshi Iwata, Yukiko Kishi , Acute adrenal failure associated with fluconazole after administration of high-dose cyclophosphamide, American Journal of Haematology, pp. 303-305, 2002 |
| Read_full_article: | pdf/18-2008/SU08Hermenean2.pdf |
| Correspondence: | Anca Hermenean, Department of Histology, Faculty of Medicine, “Vasile Goldiş” Western University, 91-94 Revolution Avenue, Arad, Romania, e-mail: anca.hermenean@gmail.com |
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Read full article |
| Article Title: | Adrenal glands morpho-functional damages at wistar rats after chemotherapy administration |
| Authors: | Anca Hermenean, Aurel Ardelean, Constantin Crăciun |
| Affiliation: | 1 Faculty of Medicine, “Vasile Goldiș” Western University, Arad, Romania 2 Electron Microscopy Center, “Babes-Bolyai” University, Cluj-Napoca, Arad, Romania |
| Abstract: | Most of cancer drugs used in chemotherapy induce most of the time strong immunosuppresive states and lymphotoxic effects, characterized especially by the alteration of lymphoid tissues. The aim of this study is to reveal stress conditions adrenals response after given chemotherapy as the connections between immune and endocrine system are well known. Giving 40 mg/kg body/day cyclophosphamide (CFA) therapy to rats by 3 days consecutively i.p. injections, can determine morphological and structural damages of the studied organs. The 24 hours adrenals histopathological and electron microscopy examination after CFA last dose administration proved the installations of some structural changes especially in the glomerulosa and fasciculata zone of adrenal cortex. |
| Keywords: | cyclophosphamide, adrenal glands morpho-functional damages |
| References: | Blank JA, Joiner RL, Houchens DP, Dill GS, Hobson DW. Comparative immunotoxicity of 2,2′- dichlorodiethyl sulfide and cyclophosphamide: evaluation of L1210 tumor cell resistance, cellmediated immunity, and humoral immunity.Int J Immunopharmacol.13(2-3):251-7, 1991 Giurgea R., Corelaţii endocrino-imunitare, Ed Risoprint, p. 166, 1994 Karp j, Szczytkowski J, Gentile C, Noradrenergic responses of peripheral organs to cyclophosphamide in mice, Life Science, Volume 75,Issue 17, pp. 2077-2089, 2004 Luster M, Portier C, Pait D, Rosenthal G, Germolec D, Corsini E, Blaylock B, Pollock P, Kouchi Y, Craig W. Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests. Fundam Appl Toxicol. 21 (1):71-82, 1993 Paşca C., Crăciun C., Ardelean A., Efecte secundare ale unor citostatice asupra organismului, Ed. Risoprint, Cluj-Napoca, p. 307, 2000 Paşca C., Miclăuş V., Ardelean A., Kis E., Sandu D., Crăciun V., papuc I., Structural and ultrastructural aspects of the rat thymus after carboplatin chemotherapy, Current Problems in Cellular and Molecular Biology, vol.V, C.Crăciun, A.Ardelean editors, Ed.Risoprint Cluj-Napoca, pp. 276-284, 2000 Shigeru Shibata , Masahiro Kami , Yoshinobu Kanda , Utako Machida , Hiroshi Iwata, Yukiko Kishi , Acute adrenal failure associated with fluconazole after administration of high-dose cyclophosphamide, American Journal of Haematology, pp. 303-305, 2002 |
| *Correspondence: | Anca Hermenean, Department of Histology, Faculty of Medicine, “Vasile Goldiş” Western University, 91-94 Revolution Avenue, Arad, Romania, e-mail: anca.hermenean@gmail.com |
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