Light microscopy study on myofibril formation and mitotic potential in human myocardocytes

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Article Title:	Light microscopy study on myofibril formation and mitotic potential in human myocardocytes
Authors:	Marinaş I.D., Marinaş Raluca, Mogoantă L.
Affiliation:	1 Emergency County Hospital 1, Craiova; 2 Department of Histology, University of Medicine and Pharmacy Craiova
Abstract:	Myocardocyte myofibril formation has been extensively studied in animal models, and in vitro, for both its importance during embryogenesis and for its putative role in a possible treatment for severe heart diseases accompanied by myocardocyte loss. However not much is known about the actual stages during the embrio life, when the myofibrils can first be observed, or how is their mitotic potential related to this functional maturation. In the present work we performed a 1 week time step sweep analysis on the myofibril formation and mitotic activity of human myocardial tissue between <3 weeks to 20 weeks of life. Thus we found out that myofibrils began to be observed at around 15 weeks of life and the myocardocytes retain their mitotic potentials until later after the myofibril formation has started.
Keywords:	myofibril formation, myocardocytes, PCNA, embryonic life
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*Correspondence:	Ionel Marinas , MD , PhD student, Department of Histology, University of Medicine and Pharmacy Craiova, Petru Rares street 2, Craiova, Romania; Email: ionel_marinas@yahoo.com