Potential protective role of selenium in acrylamide intoxication. A biochemical study

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Article Title:	Potential protective role of selenium in acrylamide intoxication. A biochemical study
Authors:	Vlad Teodor, Magdalena Cuciureanu, Bogdan-Gabriel Slencu, Nina Zamosteanu, Rodica Cuciureanu
Affiliation:	1Faculty of Pharmacy, Department of Environmental and Food Chemistry, University of Medicine and Pharmacy Gr. T. Popa Iasi 2Faculty of Dental Medicine, Department of Pharmacology, University of Medicine and Pharmacy Gr. T. Popa Iasi 3 Faculty of Medicine, Department of Biochemistry, University of Medicine and Pharmacy Gr. T. Popa Iasi
Abstract:	Acrylamide, a neurotoxic and carcinogenic chemical compound is formed by frying, roasting, grilling or baking carbohydrate-rich foods at temperatures above 120°C. Acrylamide intake is associated with significantly altered levels of total cholesterol, LDL-cholesterol, triglycerides, creatinine, urea and uric acid in the blood. This study investigates the effect of selenium (as sodium selenite and as a dietary supplement – Celnium®) on the evolution of some biochemical parameters, in Wistar rats, which received high doses of acrylamide. The administration of sodium selenite and Celnium® produced an improvement in liver cell integrity (decrease in aspartate aminotransferase (AST) activity and iron blood level), liver activities (decrease in direct bilirubin, total bilirubin, total cholesterol, LDL-cholesterol) and renal function (decrease in creatinine, uric acid and urea levels) in the treated groups as compared to the group which received only acrylamide.
Keywords:	acrylamide, biochemical parameters, dietary supplement, selenium
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*Correspondence:	Cuciureanu Rodica, University of Medicine and Pharmacy Gr. T. Popa Iasi, 16 Universitatii Street, 700115, Iasi, Romania E-mail: rcuciur@yahoo.com