Effects of Hypericum perforatum and Hypericum maculatum extracts administration on some morphological and biochemical parameters in rat liver intoxicated with alcohol

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Article Title:	Effects of Hypericum perforatum and Hypericum maculatum extracts administration on some morphological and biochemical parameters in rat liver intoxicated with alcohol
Authors:	Ioana Roman, Mihai Cristescu, Constantin Puică
Affiliation:	1 Animal Physiology Laboratory, Institute of Biological Research, Cluj-Napoca, Romania 2 University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania
Abstract:	The aim of the experiment was to study the effects of two different alcoholic extracts, containing 0.3% and 0.15% Hypericin, of two different species of Hypericum (H. Perforatum L. And H. Maculatum Crantz.) On some biochemical and morphological parameters in rats liver. Extracts were administered for 10 days in white female Wistar rats, weighing 200 ± 20 g, that were previously intoxicated with alcohol (6g/kg body) for 35 days. We found that the most effective curative effect (hepatoprotective and immunostimulating), proved to be those of Hypericum perforatum, with a content of 0.15% hypericin (hyp2 group), as well as for Hypericum maculatum, 0.15% hypericin (hym2). On the other hand, administration of alcoholic extract of Hypericum perforatum containing 0.3% ypericin/kg corp (hyp1 group) resulted in increases of morphological changes induced by treatment with alcohol.
Keywords:	hypericum perforatum, hypericum maculatum, alcohol, liver, rats
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*Correspondence:	Ioana Roman, Institute of Biological Research, 48 Republicii Str., PC 400015, Cluj-Napoca, Romania, Tel/Fax: +40-(0264)-591238, e-mail: ioanaroman65@yahoo.com