Phase solubility studies and scanning electron microscopy of dexamethasone inclusion complexes with B-cyclodextrin and hydroxypropyl B-cyclodextrin

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Article Title:	Phase solubility studies and scanning electron microscopy of dexamethasone inclusion complexes with B-cyclodextrin and hydroxypropyl B-cyclodextrin
Authors:	Mariuca-Roxana Gavriloaia, Emma-Adriana Budura, Corina Arama, Mihai Nitulescu, Dumitru Lupuleasa
Affiliation:	Pharmaceutical Technology Department, Analytical Chemistry Department „Carol Davila” University of Medicine and Pharmacy, Bucharest,
Abstract:	Dexamethasone, Dxm, is frequently used as an immunosuppressive to treat a broad range of autoimmune and inflammatory disorders, most of them occur locally and near the body surface. So, topical application could offer the advantage of delivering a drug directly to the affected surface, but barrier properties of skin limit the dexamethasone’s permeability. Transdermal penetration could be improved by drug complexation with cyclodextrins. The purpose of this paper is to analyze the formation of inclusion complexes of the drug with β-cyclodextrin and hydroxypropyl-β-cyclodextrin. Investigations were made by phase solubility diagrams and scanning electron microscopy in order to evaluate: the formation of 1:1 molar ratios, complexation efficiency, improved solubility, morphology and homogeneity samples. Huguchi and Connors method and fractal analysis were applied to compare the performances of the two final binary solutions.
Keywords:	dexamethasone, cyclodextrins, inclusion complex, phase solubility diagram, fractal analysis
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*Correspondence:	Mariuca-Roxana GAVRILOAIA*, „Carol Davila” University of Medicine and Pharmacy, Bucharest, Faculty of Pharmacy, 6 Traian Vuia St., 020956, Bucharest, Romania; e-mail: roxana21g@yahoo.com.