The effect of a topical treatment based on Sambuci flos extract in experimental thermal third degree skin burns

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Article Title:	The effect of a topical treatment based on Sambuci flos extract in experimental thermal third degree skin burns
Authors:	George Dan Mogoşanu1, Florina Carmen Popescu2, Cristina Jana Busuioc2, Oltin Tiberiu Pop2, Horia Pârvănescu3, Ioan Lascăr4, Laurenţiu Mogoantă2*
Affiliation:	1Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy; 2Research Center for Microscopic Morphology and Immunology; 3Department of Plastic Surgery and Reconstructive Microsurgery, University of Medicine and Pharmacy of Craiova; 4Department of Plastic Surgery and Reconstructive Microsurgery, “Carol Davila” University of Medicine and Pharmacy, Bucharest
Abstract:	In the European ethnopharmacology, elder flowers are used external in poultices for the treatment of burns and blisters. Sambuci flos tincture was prepared and physico-chemically analyzed according to Romanian Pharmacopoeia. The soft extract, obtained from tincture, was embedded in an ointment base of cold cream type, prepared according to United States Pharmacopoeia. The study was performed on three groups of adult male Wistar rats, each of ten animals, kept under standard conditions, both before and after the burns. Skin burns from the dorsal region were treated daily as follows: cold cream with 10% Sambuci flos extract (SFE) for the first group; 1% silver sulfadiazine cream (SDA) for the second group; the third group, considered as control, received the cold cream base (CCB). The favorable evolution of burnt skin wounds in the SFE group, compared to SDA and CCB groups, is mainly due to the astringent, anti-inflammatory, antiseptic and cicatrizing action of the natural product.
Keywords:	Sambuci flos, extract, cold cream, topical treatment, third degree skin burns
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*Correspondence:	Laurenţiu Mogoantă, Professor, MD, PhD, Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, 2–4 Petru Rareş Street, 200349 Craiova, Romania; Phone +40251–523 654, e-mail: laurentiu_mogoanta@yahoo.com