The value of global myocardial index to detect cardiac dyssynchrony in patients with non-ischemic dilated cardiomyopathy

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Article Title:	The value of global myocardial index to detect cardiac dyssynchrony in patients with non-ischemic dilated cardiomyopathy
Authors:	Mihaela Nicolin, Cristian Mornos, Adina Ionac, Aniko Mornos, Sorin Pescariu, Stefan-Iosif Dragulescu
Affiliation:	1 “Victor Babes” Timisoara University of Medicine and Pharmacy, Timisoara, Romania 2MD, PhD, “Victor Babes” Timisoara University of Medicine and Pharmacy, Timisoara, Romania 3MD, PhD, “Victor Babes” Timisoara University of Medicine and Pharmacy, Timisoara, Romania 4MD, “Victor Babes” Timisoara University of Medicine and Pharmacy, Timisoara, Romania 5MD, PhD, “Victor Babes” Timisoara University of Medicine and Pharmacy, Timisoara, Romania 6MD, Prof, PhD, FESC, “Victor Babes” Timisoara University of Medicine and Pharmacy, Timisoara, Romania
Abstract:	A variety of parameters has been proposed in left ventricular (LV) asynchrony evaluation. Echocardiography was performed in 95 patients with non-ischemic dilated cardiomyopathy (DCM). Global myocardial index (GMI) and time to peak systolic velocity (Ts) was measured from the beginning of the QRS complex to the peak myocardial systolic velocity. Absolute difference in Ts between any two of the four basal LV segments, absolute difference in Ts between any two of the six basal LV segments, absolute difference in Ts between any 2 of the 12 (6 basal and 6 mid) LV segments, and standard deviation of Ts of the 12 (6 basal and 6 mid) LV segments were derived. A composite score was calculated combining the above four dyssynchrony parameters. All GMI differed significantly among dyssynchrony groups. The area under ROC-curve to detect patients with all four criteria of dyssynchrony was 0.94 for GMI (100% sensitivity, 90% specificity). In conclusion, GMI could be used as simple index to detect LV desynchronization in DCM.
Keywords:	Cardiac dyssynchrony, Global myocardial index, Tissue Doppler Imaging
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*Correspondence:	Nicolin Roxana Mihaela “Victor Babes” Timisoara University Of Medicine And Pharmacy Timisoara, Str PP Carp, Nr 13A Romania Tel: 0040256207355 Fax: 0040256207362 E-Mail: nicolinmihaela@yahoo.com