Programmed cell death of erythrocyte, an apoptotic phenomenon. Impact on blood transfusion

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Article Title:	Programmed cell death of erythrocyte, an apoptotic phenomenon. Impact on blood transfusion
Authors:	Bratosin Daniela 1,2, Coralia Cotoraci 3, Jerome Estaquier 4
Affiliation:	1 National Institute for Biological Science Research and Development, Bucharest, Romania 2 Vasile Goldis “Western University of Arad, Faculty of Biology, Arad, Romania 3 Vasile Goldis” Western University of Arad, Faculty of Medicine, Arad, Romania 4 Unité INSERM U 841, Créteil Henri Mondor, Créteil, France
Abstract:	Human red blood cells are terminally differentiated cells of the erythroid lineage that are devoid of organelles and have a definite life span of 120 days that is ended by a process of senescence leading to their clearance from the circulation (Bratosin D. et al.,1998). Every day, 360 billions of RBCs are phagocytized, ie 5 millions per second. This fascinating phenomenon of programmed cell death (PCD) raises the following questions: i) what signals the death sentence of RBCs; ii) what are the physiological mechanisms for sequestration of the effete RBDs from the blood stream with such precision? and iii) by what specific membrane signal(s) do the reticulo-endothelial cells distinguish between the truly senescent RBCs and others?
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*Correspondence:	Bratosin D