Immunohistochemistry study on citoarchitectural modifications at placental level in case of developmental disorders and prematurity

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Article Title:	Immunohistochemistry study on citoarchitectural modifications at placental level in case of developmental disorders and prematurity
Authors:	Corina Daniela FRANDES
Affiliation:	Western University of Arad “ Vasile Goldis” Faculty of Medicine, Pharmacy and Dental Medicine
Abstract:	The hereby study aims to be a retrospective, a summary of a study on placental structural changes outlined by new researches from more than ten years. The studied lot has a statistical value being balanced, with the clinical laboratory and evolutionary arguments sufficient to allow an accurate analysis, and is representative of the studied problems, represented by morphological changes that correlate with different physiological placental variety of impaired intrauterine growth and development and perinatal consequences. Also the lot allowed through the included categories to make an analysis of placental citoarchitecture and of the fetoplacentar unit in order validate the study findings. I made these remarks because in multiple situations the analysis of morphological placenta was insufficient or superficial, losing the valuable information on product evolution and prognosis from a conceptual task with increased risk or no risk. Immunohistochemical study shows superiority in identifying structural changes of cellular and tissue intimacy at the placental level compared with morphological and histochemical methods.
Keywords:	immunohistochemistry, monoclonal antibody, placental citoarchitectonics, perinatal pathology
References:	Altshuler G. The relationship of placental pathology to causation of detrimental pregnancy outcome in fetal and neonatal brain injury, mechanisms, management, and the risks of practice, 2nd ed. In: Stevenson DK, Sunshine P. New York: Oxford University Press, 1997, pp. 585–601. Altshuler G, Deppisch L. College of American Pathologists Conference XIX on the examination of the placenta: report of the Working Group on Indications for Placental Examination, C.A.P. Placenta Consensus Conference. Arch Pathol Lab Med 1991;115:701–703. AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE ( 1999 ) – Antiphospholipid antibodis do not affect IVF success. A Practice Committee Report, October 1999. Benirschke K, Kaufmann P. The pathology of the human placenta, 3rd ed. New York: Springer-Verlag, 1995. Frandes Corina Daniela, Radu Adriana, Nanu P.D., Chendereş Ramona, G.Damian.- Identificarea imunohistochimică la nivel placentar a celulelor stromale fibroblastice/miofibroblastice-lite, expresie a CK (Cocktail a unor anticorpi monoclonali, proteine citoscheletare AE1/AE3)”. Vol VII Nr.2 din 2008 pag.155-158. ISSN 1583-4026 Frandeş Corina Daniela, Sferdian Mircea şi Damian Graţian- Sistematizarea miocitelor intraplacentare într-un sistem contractil, propriu, evidenţiere imunohisto-chimică”. Vol V, Nr.3 din 2006 pag. 44- 48. ISSN 1583-4026 Frandes Corina Daniela, Anca Oana Hermenean, Adriana Radu. -“The IHC using monoclonal anti-VIM antibody of the primary trophoblast at the placental level in different prematurity stages “ Revista Română de Anatomie funcţională şi clinică, macro-şi microscopică şi de Antropologie, vol. VIII, nr. 3 2009 pag,343-349 Ifrim M., Sălăgean V., Vinţu I., Riscul malformativ in reproducerea umană, Ed. Medicală, Bucureşti, 1978 Kaplan C, Lowell DM, Salafia C. College of American Pathologists Conference XIX on the examination of the placenta: report of the working group on the definition of structural changes associated with abnormal function in the maternal/fetal placental unit in the second and third trimesters. Arch Pathol Lab Med 1991;115:709–716. Langston C, Kaplan C, Macpherson T, et al. Practice guideline for examination of the placenta: developed by the Placental Pathology Practice Guideline Development Task Force of the College of American Pathologists. Arch Pathol Lab Med 1997;121:449–472. Maddox DE, Butterfield JH, Ackerman SJ, Coulam CB, Gleich GJ. Elevated serum levels in human pregnancy of a molecule immunochemically similar to eosinophil granule major basic protein. J Exp Med 1983;158:1211–1226. Naeye RL. Maternal floor infarction. Hum Pathol 1985;16:823–828. Khong TY. Expression of MHC class II antigens by placental villi: no relationship with villitis of unknown origin. J Clin Pathol 1995;48:494–495. Radu Adriana, Frandes Corina Daniela, Hermenean Anca Oana – “The immunohistochemical expression of alfa-FP in placentas from the births’ of encephalic pole developmental problems fetuses” Revista Română de Anatomie funcţională şi clinică, macro-şi microscopică şi de Antropologie, vol VIII, nr.4.2009 pag475-479 Salafia CM, Minior VK, Pezzullo JC, Popek EJ, Rosenkrantz TS, Vintzileos AM. Intrauterine growth restriction in infants of less than thirty-two weeks’ gestation: associated placental pathologic features. Am J Obstet Gynecol 1995;173:1049–1057. Sternberg ,J PLACENTAL TRANSFERS: MODERN METHODS OF STUDY.: American Journal of Obstetrics and Gynecology (U.S.); Journal Volume: Vol: 84
*Correspondence:	Frandes C.