Histopathological aspects in laryngeal precancerous lesions

Authors: Raluca HORHAT, Delia HORHAT*, Marioara POENARU, S. COTULBEA, Carmen PANAITESCU, N. BALICA, C. SARAU, F. HORHAT, Valeria MOCANU

Affiliation: University of Medicine and Pharmacy “Victor Babeş” Timişoara, Romania

Read full article

ABSTRACT. Carcinogens injury on the laryngeal mucosa gives birth to genetic alterations, which then translate into premalignant lesions (hyperplasia, dysplasia, in situ carcinoma). Between 2006 and 2008, 67 patients were admitted in the ENT Department in Timisoara with chronic laryngeal diseases and precancerous lesions associated. They have been investigated by suspended microlaryngoscopy and biopsy with histopathological examination. Hyperplasia was the most frequent lesion (65.67%) associated with chronic laryngitis, laryngeal papilloma, laryngeal polyp and Reinke oedema. Mild dysplasia was present in 7.46% of the cases, moderate dysplasia in 14.92% and the severe form in 1.49% of the cases. The carcinoma in situ has been diagnosed in 7 patients (10.44%).

Keywords: chronic laryngitis, polyp, papilloma, hyperplasia, dysplasia, carcinoma in situ