Histochemical and biochemical analysis regarding the protective effects of some bioactive compounds in the brain of rabbit fetuses prenatally exposed to some excitotoxins

Authors: Constantin PUICĂ¹*, Mircea RUSU¹, Mihai CRISTESCU², Ioana ROMAN¹, Maria BORSA¹

Affiliation: ¹ Institute of Biological Research Cluj-Napoca, Romania; ² University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania

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ABSTRACT. Administration of L-monosodium glutamate (MSG), L-aspartate (ASP) and L-cysteine (CYS), in the organogenesis period (6-18 days) of gestation in rabbits induced a reduction of the nuclear DNA and RNA fluorescence in all neuronal brain populations, and a significant decrease of DNA and protein quantity in total brain homogenate, comparative to control group Administration of MSG, ASP and CYS associed with a vitamin-mineral bioactive complex in the same period of gestation shows a moderate diminution of the DNA and RNA fluorescence, in all neuronal brain structures, and a moderate decrease of DNA and protein quantity comparative to C group.

Keywords: excitotoxins, bioactive complex, gestation, rabbits, DNA, RNA fluorescence, DNA, protein quantity