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CNCSIS B+ (code 820) since 2007

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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Comparative bioinformatic analysis of Cytochrome C Oxidase Subunit1 genes and proteins across several mammalian species Print E-mail
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Article Title: Comparative bioinformatic analysis of Cytochrome C Oxidase Subunit1 genes and proteins across several mammalian species
Authors: Manavipour M., Modarresi M.
Affiliation: 1 Department of Animal Science, Faculty of Agriculture, Tarbiat Modares University, Tehran, 14115 - 336, I. R. Iran 2Rice Research Institute of Iran, Agricultural Research, Education and Extension Organization (AREEO), Rasht, Iran
Abstract: Cytochrome c oxidase enzyme has an important role in the mitochondrion electron transport chain, plays several main roles in aerobic cellular respiration. In the present study, we have obtained the relation between nucleotide, amino acids and promoter region for the human and mouse Cytochrome c oxidase1 (COI, also COX1). Raw data was retrieved from NCBI and Uniprot websites. Promoter predictions for human and mouse COX1 gene showed that this gene had several common transcription factors such as CREB binding protein, important to histone transcriptional activation, Cation transport regulator homolog 1 (ChaC1), involved in breast and ovarian cancer. Mammalian COI protein sequences were analyzed by the application of bioinformatical tools to predict the protein properties based on biophysical properties, major motifs, conserved domains and transmembrane regions, similar characteristics, secondary and spatial structures. In addition, a relationship among mammalians COI gene was proved by Phylogenetic analysis. Network analysis has indicated that COX1 is closely related to MT-CO2, MT-CO3 and MT-CYB.
Keywords: MT-CO1, comparative analysis, prediction, conserved regions
*Correspondence: Mostafa Modarresi, This e-mail address is being protected from spambots. You need JavaScript enabled to view it