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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Formulation and manufacturing process of some chewable tablets containing carbamazepine – β – cyclodextrin inclusion complex Print E-mail
Written by Abdalrb G.A., Budura E.A., Toderescu C.D., Sârbu I.   

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Article Title: Formulation and manufacturing process of some chewable tablets containing carbamazepine – β –  cyclodextrin inclusion complex
Authors: Abdalrb G.A., Budura E.A., Toderescu C.D., Sârbu I.
Affiliation: University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia St., 020956, Bucharest, Romania

Abstract: Carbamazepine, the most widely used anticonvulsant in the world, has a variable and delayed absorption and a low oral bioavailability due to its poor aqueous solubility. In order to increase its dissolution, we choose to include it in the cavity of beta-cyclodextrin (β-CD), and the solid binary system was prepared in a 1:1 molar ratio by kneading technique. The inclusion complex was used as the active ingredient in a formulation of chewable tablets. The first party of our study presents the preformulation studies on the powder obtained after mixing the active ingredient with the excipients for direct compression (F-MELT® and magnesium stearate). After we established that our material has a good fowability and compressibility, the chewable tablets were prepared using the direct compression method. The final part of the study presents the pharmacotechnical properties of the tablets.
Keywords: Carbamazepine, Inclusion complex, beta-cyclodextrin, chewable tablets
*Correspondence: Emma Adriana Budura , University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia St., 020956, Bucharest, Romania,  email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it