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Index Copernicus Value (2010): 5.45
CNCSIS B+ (code 820) since 2007

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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Qualitative assessment of some hydrogels containing ketoprofen Print E-mail
Written by Toderescu C.D., Dinu-Pîrvu C.E., Ghica M.V., Anuţa V., Vlaia L., Lupuliasa D.   
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Article Title: Qualitative assessment of some hydrogels containing ketoprofen
Authors: Toderescu C.D., Dinu-Pîrvu C.E., Ghica M.V., Anuţa V., Vlaia L., Lupuliasa D.
Affiliation: 1Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2Faculty of Pharmacy, Department of Pharmaceutical Sciences, ”Vasile Goldis” Western University of Arad, Romania 3Faculty of Pharmacy, University of Medicine and Pharmacy, Timisoara, Romania
Abstract: This paper is a complex biopharmaceutical study that analyses the formulation of some hydrogels intended for cutaneous use, which favour a rapid release of the active substance from the designed vehicles onto and through the skin surface. The influence of the gel-forming polymer type on the main quality parameters of hydrogels with ketoprofen was assessed. Through the experiments conducted the organoleptic control, pH determination, drug content and spreadability were carried out for the formulations. A study of the rheological properties characteristic for the designed hydrophilic gels was also performed and the relation between their flow properties and both the structure and composition was further analyzed. This characterization contributes to the design evaluation and the optimization of semisolid pharmaceutical systems, in order to be used for specific purposes.
Keywords: carbomer 940, hydroxyethylcellulose, ketoprofen, hydrogel
*Correspondence: Cristina Elena Dinu-Pîrvu, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania This e-mail address is being protected from spambots. You need JavaScript enabled to view it