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Rank:
Index Copernicus Value (2010): 5.45
CNCSIS B+ (code 820) since 2007

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SCOPUS since 2009
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Genamics JournalSeek since 18/2008

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Oxford University's Library since 2003

Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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The pyrazole scaffold in drug development. A target profile analysis Print E-mail
Written by Niţulescu G.M., Nedelcu G., Buzescu A., Velescu B.Ș, Olaru O.T.   
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Article Title: The pyrazole scaffold in drug development. A target profile analysis
Authors: Niţulescu G.M., Nedelcu G., Buzescu A., Velescu B.Ș, Olaru O.T.
Affiliation:
Abstract: The study investigates the pyrazole ring as a scaffold in drug development, focusing on identifying its privileged biological targets. Molecular descriptors distributions were used for characterizing the pharmacologically active pyrazole derivatives in order to provide rule of thumb for design of new drug like pyrazoles. The analysis of the biological interaction profiles demonstrated a class-selectivity of these compounds toward protein kinases involved in cancer pathology, highlighting the importance of the pyrazole moiety in the development of new antitumor drugs. Several other targets with implications in different pathologies were revealed. Our study indicates the pyrazole ring as an attractive framework for drug discovery, pyrazole-based derivatives being capable of serving as ligands for a diverse array of molecular substrates, depending on the varying substituents.
Keywords: privileged scaffolds, target affinity patterns, database mining, adenosine bioisoster, virtual screening


*Correspondence: Anca Buzescu , Carol Davila” University of Medicine and Pharmacy, Traian Vuia 6, Bucharest 020956, Romania  E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it