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Index Copernicus Value (2010): 5.45
CNCSIS B+ (code 820) since 2007

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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Selection of an efficient chondroitin sulfate-liposome delivery system as chondroprotective agent for local inflammation treatment Print E-mail
Written by Craciunescu O., Moldovan L., Moisei M., Utoiu E., Zarnescu O., Roseanu A., Trif M.   
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Article Title: Selection of an efficient chondroitin sulfate-liposome delivery system as chondroprotective agent for local inflammation treatment
Authors: Craciunescu O., Moldovan L., Moisei M., Utoiu E., Zarnescu O., Roseanu A., Trif M.
Affiliation: Department of Cellular and Molecular Biology, The National Institute of Research & Development for Biological Sciences, 296, Splaiul Independentei, sector 6, 060031, Bucharest, Romania
The Institute of Biochemistry of the Romanian Academy, 296, Splaiul Independentei, sector 6, 060031,Bucharest, Romania
The University of Bucharest, Faculty of Biology, 91-95, Splaiul Independentei, sector 5, 76201, Bucharest, Romania
Abstract: We aimed to select a biocompatible concentration of chondroitin sulfate loaded in liposomes (L-CS) in a culture of human chondrocytes for its possible use in intra-articular treatment of inflammatory and degenerative disorders. L-CS effect on cell viability and morphology and its anti-inflammatory effect was investigated in cell culture experimental models. Our data demonstrated that 250-500 µg/ml CS from L-CS formulation was the optimal range concentration for in vitro experiments. L-CS was more efficient than free CS in preventing cell morphology changes and inhibiting gelatinases secretion in the culture medium of inflamed cells. In conclusion, CS loaded in liposomes could be efficient an chondroprotective agent for intraarticular treatment of osteoarthritis.
Keywords: chondroitin sulfate, liposomes, chondrocytes, cytotoxicity, metalloproteinases
References:
*Correspondence: Dr. Lucia Moldovan, The National Institute of Research & Development for Biological Sciences, 296, Splaiul Independentei, sector 6, 060031, Bucharest, Romania, Tel/fax: +40-21-2200882, Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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