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Rank:
Index Copernicus Value (2010): 5.45
CNCSIS B+ (code 820) since 2007

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SCOPUS since 2009
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Directory of Open Access Journals (DOAJ) since 2008
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Genamics JournalSeek since 18/2008

International Catalogues:
Oxford University's Library since 2003

Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Studies on the formulation of nanostructured carriers for increasing the bioavailability of Pralidoxime Chloride Print E-mail
Written by Orbesteanu A-M, Cojocaru V., Ailiesei I., Mircioiu C.,Cinteza L.O.   
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Article Title: Studies on the formulation of nanostructured carriers for increasing the bioavailability of Pralidoxime Chloride
Authors: Orbesteanu A-M, Cojocaru V., Ailiesei I., Mircioiu C.,Cinteza L.O.
Affiliation: 1 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest
2Faculty of Chemistry, University of Bucharest
Abstract: The life threatening intoxication with highly toxic organophosphorous nerve agents requires the immediate administration of antidotes such as oximes. For the standard treatment of this intoxication, pralidoxime chloride (PAM) proved to be one of the most important antidotes. This study focused on the formulation of modern colloidal vectors for the delivery of pralidoxime chloride, such as liposomes and cubosomes. Taking into consideration the fact that this drug owns a low bioavailability, due to its high hydrophilicity, the formulation aimed at improving this behaviour.
Keywords: nanotechnology, liposomes, cubosomes, oximes, pralidoxime chloride
References:
*Correspondence: Orbesteanu Ana-Maria, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it