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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Pharmacodynamic and pharmacokinetic studies on novel vanadyl chrysin complex Print E-mail
Written by Velescu B. S., Uivarosi V., Anuta V., Buzescu A., Negres S.   
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Article Title: Pharmacodynamic and pharmacokinetic studies on novel vanadyl chrysin complex
Authors: Bruno Stefan Velescu, Valentina Uivaroşi, Valentina Anuţa, Anca Buzescu, Simona Negreş
Affiliation: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Department of Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Department of Physical chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Abstract: A novel complex with general formula VO(chrysin) ·4H O was studied in order to evaluate its’ 2 2 pharmacodynamic action, and its’ pharmacokinetic properties. The hypoglycemic activity of the complex was evaluated in an alloxan diabetic rat model, and compared to chrysin and vanadyl sulphate. The pharmacokinetic properties were studied following a single dose administration, in compartmental and non-compartmental analyses. The complex has a low toxicity and a low hypoglycemic effect (p>0.05) correlated with the pharmacokinetic parameters (volume of distribution, half time and micro-constants).
Keywords: vanadyl chrysin complex, pharmacodynamic action, pharmacokinetic properties, hypoglycemic activity
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