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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Programmed cell death of erythrocyte, an apoptotic phenomenon. Impact on blood transfusion Print E-mail
Written by Bratosin D., Cotoraci C, Jerome E.   
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Article Title: Programmed cell death of erythrocyte, an apoptotic phenomenon. Impact on blood transfusion
Authors: Bratosin Daniela 1,2, Coralia Cotoraci 3, Jerome Estaquier 4
Affiliation: 1 National Institute for Biological Science Research and Development, Bucharest, Romania
2 Vasile Goldis “Western University of Arad, Faculty of Biology, Arad, Romania
3 Vasile Goldis” Western University of Arad, Faculty of Medicine, Arad, Romania
4 Unité INSERM U 841, Créteil Henri Mondor, Créteil, France
Abstract: Human red blood cells are terminally differentiated
cells of the erythroid lineage that are devoid of organelles
and have a definite life span of 120 days that is ended by
a process of senescence leading to their clearance from
the circulation (Bratosin D. et al.,1998).
Every day, 360 billions of RBCs are phagocytized,
ie 5 millions per second. This fascinating phenomenon
of programmed cell death (PCD) raises the following
questions: i) what signals the death sentence of RBCs; ii)
what are the physiological mechanisms for sequestration
of the effete RBDs from the blood stream with such
precision? and iii) by what specific membrane signal(s)
do the reticulo-endothelial cells distinguish between the
truly senescent RBCs and others?
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*Correspondence: Bratosin D