SCImago Journal & Country Rank

Ranking and Indexing

Index Copernicus Value (2010): 5.45
CNCSIS B+ (code 820) since 2007

International Databases:
SCOPUS since 2009
EBSCO Academic Search Complete since 2008
Index Copernicus Journals Master List since 2009
Directory of Open Access Journals (DOAJ) since 2008
Genamics JournalSeek since 18/2008

International Catalogues:
Oxford University's Library since 2003

Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

Who's Online

We have 293 guests online

Index Databases

Colorectal cancer risk assessment using molecular biology techniques Print E-mail
Written by Ardelean A.   
Read full article
Article Title: Colorectal cancer risk assessment using molecular biology techniques
Authors: Aurel Ardelean
Affiliation: “Vasile Goldis” Western University Arad, Romania
Academy of Romanian Scientists
Abstract: Colorectal cancer is a major health burden, despite advances in surgical treatment and chemotherapy, being the most common cancer and second leading cause of cancer death in both sexes in European Union. In colorectal cancer, various molecular biology techniques are extensively used to identify valuable biomarkers for predicting the clinical outcome and response to treatment. The aim of our study was to evaluate the role of different molecular biology methods in assessing colorectal cancer risk. We included in this study patients diagnosed with colorectal cancer (n=286) and healthy controls (n=190). All diagnoses were pathologically confirmed. Written consent for participation was obtained from all study subjects. DNA and mRNA were obtained from blood and tissue samplesets. We investigated the risk of colorectal cancer by different techniques addressing multiple targets. ANKRD17 mRNA, VEGF +936 C/T and -634 G/C polymorphisms, mutations in codon 12 of the K-ras gene and Gly120Ala in p53 gene appear to be the most sensitive targets and may have a potential value as additional markers for the risk assessment and prognostic of colorectal cancer.
Keywords: colorectal cancer, molecular targets, K-ras, p53
References: Chirila D. N., Pop T. R., Turdeanu N. A., Tubular carcinoid tumor of the appendix – a clinical case, HVM Bioflux, 3(1), pp.1-4, 2011
Douillard J-.Y., Cunningham D., Roth A. D., et al., Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomized trial, Lancet, 355, pp. 1041–1047, 2000.
Kataria N., Kataria A. K., Pandey N., Gupta P., Serum biomarkers of physiological defense against reactive oxygen species during environmental stress in Indian dromedaries, HVM Bioflux, 2(2), pp.55-60, 2010
Kinzler K. W., Wogelstein B., Lessons from hereditary colorectal cancer, Cell, 87, pp.159-170
Mihociu T., Belc N., Iorga E., Rusu L., Metaxa I., The use of PCR applications for assessment of Clostridium botulinum presence in the culture environment and fish samples in the conditions of open system production from Romanian fisheries, AACL Bioflux, 3(4), pp.289-298, 2010
Pasarin B., The Pricopian «gene theory of sexuality» is just a hypothesis, but good enough to explain the sex determination in fish, AACL Bioflux, 3(2), pp.141-150, 2010
Petrescu-Mag I. V., Winge’s sex-linked color patterns and SDL in the guppy: genes or gene complexes?, AACL Bioflux, 2(1), pp.71-80, 2009
Srivastava S., Verma M., Henson D. E., Biomarkers for early detection of colon cancer, Clin Cancer Res, 7, pp.1118-1126, 2001
*Correspondence: Aurel Ardelean, “Vasile Goldis” Western University Arad, Romania, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it