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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Correlation between podocyte foot process effacement and proteinuria in human glomerular diseases Print E-mail
Written by Spanu S., Craciun C., Spanu C., Gherman-Caprioara   
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Article Title: Correlation between podocyte foot process effacement and proteinuria in human glomerular diseases
Authors: Silvia Spânu, Constantin Crăciun, Costel Spânu, Mirela Gherman-Căprioară
Affiliation: 1 University of Medicine and Pharmacy “I.Haţieganu” , Department of Nephrology, Cluj-Napoca, Romania
2 University “Babeş – Bolyai” , Electron Microscopy Center, Cluj-Napoca, Romania
Abstract: The podocyte is a specialized epithelial cell with numerous interdigitating foot processes which play an important role in the regulation of the glomerular basement membrane (GBM) permeability. The nephrotic syndrome results from increased glomerular permeability to proteins and is structurally belived to be associated with podocyte foot process effacement. Despite increasing knowledge of the molecular composition of the glomerular filtration barrier, the relationship between proteinuria and foot process effacement remains unclear. The aim of this study is to analyze the relationship between podocyte foot process effacement and the level of proteinuria. Morphometric analysis was performed on electron microscopy images taken randomly from 37 patients diagnosed with various glomerular diseases. 17 of the patients had nephrotic syndrome and 20 had subnephrotic proteinuria. The mean foot process width (FPW) was quantitated for each patient and for each group and correlated with the level of proteinuria. In the non nephrotic group segmental effacement of the foot processes was present and the mean FPW was 422 ± 90 nm. In the nephrotic group the foot processes were diffusely effaced, reflected by a FPW of 1196 ± 517 nm, significantly larger than in the subnephrotic group. The level of proteinuria correlated with the FPW only when all 37 patients were analyzed together. There was no correlation when the groups were studied separately. The mean FPW was significantly larger in the nephrotic group compared to the non nephrotic group. Podocyte foot process effacement correlated with proteinuria.
Keywords: podocyte, foot process effacement, foot process width, proteinuria
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*Correspondence: Silvia Spânu, University of Medicine and Pharmacy “I.Haţieganu”, Department of Nephrology, Cluj-Napoca, Clinicilor St., no. 3-5, 400006, Cluj-Napoca, Romania, Tel. +40745192191, email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it