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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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Light microscopy study on myofibril formation and mitotic potential in human myocardocytes Print E-mail
Written by Marinas I.D., Marinas R., Mogoanta L.   
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Article Title: Light microscopy study on myofibril formation and mitotic potential in human myocardocytes
Authors: Marinaş I.D., Marinaş Raluca, Mogoantă L.
Affiliation: 1 Emergency County Hospital 1, Craiova;
2 Department of Histology, University of Medicine and Pharmacy Craiova
Abstract: Myocardocyte myofibril formation has been extensively studied in animal models, and in vitro, for both its importance during embryogenesis and for its putative role in a possible treatment for severe heart diseases accompanied by myocardocyte loss. However not much is known about the actual stages during the embrio life, when the myofibrils can first be observed, or how is their mitotic potential related to this functional maturation. In the present work we performed a 1 week time step sweep analysis on the myofibril formation and mitotic activity of human myocardial tissue between <3 weeks to 20 weeks of life. Thus we found out that myofibrils began to be observed at around 15 weeks of life and the myocardocytes retain their mitotic potentials until later after the myofibril formation has started.
Keywords: myofibril formation, myocardocytes, PCNA, embryonic life
References: Burrage, T. G. and Sherman, R. G. (1979). Formation of sarcomeres in the embryonic heart of the lobster. Cell Tissue Res. 198, 477-486.
Ferreira, P. J., L’Abbate, C., Abrahamsohn, P. A., Gouveia, C. A., and Moriscot, A. S. (2003). Temporal and topographic ultrastructural alterations of rat heart myofibrils caused by thyroid hormone. Microsc. Res. Tech. 62, 451-459.
Fujii, S., Hirota, A., and Kamino, K. (1981). Optical indications of pace-maker potential and rhythm generation in early embryonic chick heart. J Physiol 312, 253-263.
Jorgensen, A. O. and Bashir, R. (1984). Temporal appearance and distribution of the Ca2+ + Mg2+ ATPase of the sarcoplasmic reticulum in developing chick myocardium as determined by immunofluorescence labeling. Dev. Biol. 106, 156-165.
Kruithof, B. P., van den Hoff, M. J., Wessels, A., and Moorman, A. F. (2003). Cardiac muscle cell formation after development of the linear heart tube. Dev. Dyn. 227, 1-13.
Lyons, G. E. (1996). Vertebrate heart development. Curr. Opin. Genet. Dev. 6, 454-460.
Markwald, R. R. (1973). Distribution and relationship of precursor Z material to organizing myofibrillar bundles in embryonic rat and hamster ventricular myocytes. J Mol. Cell Cardiol. 5, 341-350.
Mercola, M., Ruiz-Lozano, P., and Schneider, M. D. (2011). Cardiac muscle regeneration: lessons from development. Genes Dev. 25, 299-309.
Rhee, D., Sanger, J. M., and Sanger, J. W. (1994). The premyofibril: evidence for its role in myofibrillogenesis. Cell Motil. Cytoskeleton 28, 1-24.
Sedmera, D. (2011). Function and form in the developing cardiovascular system. Cardiovasc. Res. Sissman, N. J. (1970). Developmental landmarks in cardiac morphogenesis: comparative chronology. Am. J Cardiol. 25, 141-148.
Tokuyasu, K. T. and Maher, P. A. (1987). Immunocytochemical studies of cardiac myofibrillogenesis in early chick embryos. I. Presence of immunofluorescent titin spots in premyofibril stages. J Cell Biol. 105, 2781-2793.
Tullio, A. N., Accili, D., Ferrans, V. J., Yu, Z. X., Takeda, K., Grinberg, A., Westphal, H., Preston, Y. A., and Adelstein, R. S. (1997). Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc. Natl. Acad. Sci U. S. A 94, 12407-12412.
van den Hoff, M. J., Kruithof, B. P., Moorman, A. F., Markwald, R. R., and Wessels, A. (2001). Formation of myocardium after the initial development of the linear heart tube. Dev. Biol. 240, 61-76.
van der, M. E., Harper, I. S., Owen, P., Lochner, A., Wynchank, S., and Opie, L. H. (1987). Ultrastructural observations on the effects of different substrates on ischaemic contracture in global subtotal ischaemia in the rat heart. Basic Res. Cardiol. 82 Suppl 2, 285-287.
Viragh, S. and Challice, C. E. (1973). Origin and differentiation of cardiac muscle cells in the mouse. J Ultrastruct. Res. 42, 1-24.
*Correspondence: Ionel Marinas , MD , PhD student, Department of Histology, University of Medicine and Pharmacy Craiova, Petru Rares street 2, Craiova, Romania; Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it