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Journal Info

Title: Studia Universitatis Vasile Goldis, Seria Stiintele Vietii (Life Sciences Series)
Abbreviated title: Studia Univ. VG, SSV
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1584-2363
e-ISSN: 1842-7863
ISSN-L: 1584-2363

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The prognostic significance of c-erbB-2 oncoprotein in lung carcinomas Print E-mail
Written by Grigoras M., Lazar E., Dema A., Cornianu M., Muresan A., Lazureanu C., Faur A.   
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Article Title: The prognostic significance of c-erbB-2 oncoprotein in lung carcinomas
Authors: Mirela Grigoraş, Elena Lazăr, Alis Dema, Marioara Cornianu, Anca Mureşan, Codruţa Lăzureanu, Alexandra Faur
Affiliation: Department of Pathology, University of Medicine and Pharmacy “Victor Babeş” Timişoara, Romania
Abstract: We assessed the immunohistochemical expression of c-erbB-2 transmembrane receptor in 15 primary lung carcinomas using the polyclonal antibody anti-human c-erbB-2 oncoprotein. Tissue fragments routinely processed (formalin-fixed and paraffin-embedded) were then investigated for c-erbB-2 oncoprotein expression using the Avidin-Biotin Complex staining method. Tumor cells showed positive c-erbB-2 expression in 86.6% of non small cell lung carcinomas (NSCLC). Positive c-erbB-2 immunoreaction correlated with the advanced stage of the disease, with lymph node involvement and high metastasis rate. The results obtained suggest that tissue overexpression of c-erbB-2 protein in NSCLC characterizes a group of tumors with an aggressive clinical-biological behavior and poor prognosis; c-erbB-2 protein can be considered a useful tumor marker in the morphological diagnosis and monitoring the clinical behavior of these neoplasms.
Keywords: lung carcinomas, immunohistochemistry, c-erbB-2 oncoprotein
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